Low-density lipoprotein reconstituted by pyropheophorbide cholesteryl oleate as target-specific photosensitizer

被引：98
|
作者：
Zheng, G
Li, H
Zhang, M
Lund-Katz, S
Chance, B
Glickson, JD
机构：
[1] Univ Penn, Sch Med, Dept Radiol, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
[3] Shanghai Univ, Dept Chem, Shanghai 200436, Peoples R China
[4] Childrens Hosp Philadelphia, Dept Pediat GI Nutr, Philadelphia, PA 19104 USA
来源：
BIOCONJUGATE CHEMISTRY | 2002年 / 13卷 / 03期
关键词：
D O I：
10.1021/bc025516h
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
To target tumors overexpressing low-density lipoprotein receptors (LDLr), a pyropheophorbide cholesterol oleate conjugate was synthesized and successfully reconstituted into the low-density lipoprotein (LDL) lipid core. Laser scanning confocal microscopy studies demonstrated that this photosensitizer-reconstituted LDL can be internalized via LDLr by human hepatoblastoma G(2) (HepG(2)) tumor cells.
引用
收藏
页码：392 / 396
页数：5
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