Stabilization of DNA duplexes by covalently-linked peptides

被引：11
|
作者：
Marchán, V [1 ]
Debéthune, L [1 ]
Pedroso, E [1 ]
Grandas, A [1 ]
机构：
[1] Univ Barcelona, Fac Quim, Dept Quim Organ, E-08028 Barcelona, Spain
来源：
TETRAHEDRON | 2004年 / 60卷 / 25期
关键词：
nucleopeptide; peptide-oligonucleotide conjugate; duplex stability; hybridization; melting temperature;
D O I：
10.1016/j.tet.2004.04.053
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The hybridization properties of various peptide-oligonucleotide hybrids were assessed front UV thermal denaturation experiments. Analysis of these and other published data suggests that peptide chains, both hydrophobic and positively charged, generally have a clear stabilizing effect on short-chain oligonucleotide duplexes. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5461 / 5469
页数：9
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