Stabilization of DNA duplexes by covalently-linked peptides

被引：11

作者：

Marchán, V ^{[1
]}

Debéthune, L ^{[1
]}

Pedroso, E ^{[1
]}

Grandas, A ^{[1
]}

机构：

[1] Univ Barcelona, Fac Quim, Dept Quim Organ, E-08028 Barcelona, Spain

来源：

TETRAHEDRON | 2004年 / 60卷 / 25期

关键词：

nucleopeptide; peptide-oligonucleotide conjugate; duplex stability; hybridization; melting temperature;

D O I：

10.1016/j.tet.2004.04.053

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The hybridization properties of various peptide-oligonucleotide hybrids were assessed front UV thermal denaturation experiments. Analysis of these and other published data suggests that peptide chains, both hydrophobic and positively charged, generally have a clear stabilizing effect on short-chain oligonucleotide duplexes. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5461 / 5469

页数：9

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