First case of AML with rare chromosome translocations: a case report of twins

被引：8

作者：

Wang, Lin ^{[1
]}

Sun, Yanhua ^{[2
]}

Sun, Yanli ^{[3
]}

Meng, Lingbin ^{[4
]}

Xu, Xin ^{[5
,6
]}

机构：

[1] Weifang Univ, Sch Phys & Optoelect Engn, Weifang 261061, Shandong, Peoples R China

[2] Weifang Med Univ, Lab Clin Lab Diagnost, Weifang 261053, Shandong, Peoples R China

[3] Weifang Peoples Hosp, Dept Hematol, Weifang 261053, Shandong, Peoples R China

[4] Florida Hosp, Dept Internal Med, Orlando, FL 32803 USA

[5] Weifang Med Univ, Affiliated Hosp, Stem Cell Lab, Weifang 261053, Shandong, Peoples R China

[6] Weifang Med Univ, Coll Biosci & Technol, 1 Bldg Room 610,288 Shenglidong St, Weifang 261042, Shandong, Peoples R China

来源：

BMC CANCER | 2018年 / 18卷

关键词：

AML; Genetic rearrangement; FLT3/ITD; WGS; DIACYLGLYCEROL KINASE-ALPHA; HEPATOCELLULAR-CARCINOMA; PROTEIN; 4; CANCER; CELLS; DHHC2;

D O I：

10.1186/s12885-018-4396-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangements may also contribute to leukemogenesis but are less summarized. Case presentation: Here we reported rare fusion genes ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15 in a 47-year-old AML-M4 patient with FLT3 internal tandem duplication (ITD) discovered by whole genome sequencing (WGS) using the patient's healthy sibling as a sequencing control. Conclusion: This is, to our knowledge, the first case of AML with fusion gene ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15.

引用

页数：4

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