BIOGENIC SILVER NANOPARTICLES AND ITS ANTIFUNGAL ACTIVITY AS A NEW TOPICAL TRANSUNGUAL DRUG

被引：12

作者：

Marcato, Priscyla D. ^{[1
]}

Duran, Marcela ^{[1
]}

Huber, Stephany ^{[1
]}

Rai, Mahendra ^{[2
]}

Melo, Patricia S. ^{[3
]}

Alves, Oswaldo L. ^{[1
]}

Duran, Nelson ^{[1
,4
]}

机构：

[1] Univ Estadual Campinas, Biol Chem Lab, Inst Quim, BR-23083970 Campinas, SP, Brazil

[2] SGB Amravati Univ, Dept Biotechnol, Amravati 444602, Marahestra, India

[3] METROCAMP, Campinas, SP, Brazil

[4] Univ Fed ABC, Ctr Nat & Human Sci, BR-09210170 Santo Andre, SP, Brazil

来源：

JOURNAL OF NANO RESEARCH | 2012年 / 20卷

基金：

巴西圣保罗研究基金会;

关键词：

TEXTILE FABRICS; CELL; HL60; CYTOTOXICITY; VIOLACEIN; TOXICITY;

D O I：

10.4028/www.scientific.net/JNanoR.20.99

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Silver nanoparticles production was monitored by UV Vis and TEM micrograph and they were obtained as spherical and homogenous nanoparticles with a size of similar to 100 nm by photon correlation spectroscopy (PCS). Silver nanoparticles, in an IC80 range of 1-2 mu g/mL, showed significant antifungal activity against T. rubrum. Cytotoxicity through hemolytic activity against erythrocytes and the viability of V79 fibroblast or HL60 cells showed less toxicity than amphotericin B. The disk diffusion test showed that the silver nanoparticles exerted a similar inhibition zone that amphotericin B by a synergistic effect when added at the same time against T. rubrum culture.

引用

页码：99 / 107

页数：9

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