Carbon-14 labeling of hydrochlorothiazide via [14C]formaldehyde production from [14C]carbon dioxide at ambient temperature

被引：1

作者：

Sandell, Johan ^{[1
]}

机构：

[1] AstraZeneca, Res & Dev, Isotope Chem Screening & Profiling Global DMPK IM, Sodertalje, Sweden

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2012年 / 55卷 / 14期

关键词：

14C]formaldehyde; Schwartz's reagent; zirconocene hydrochloride; hydrochlorothiazide; REDUCTION;

D O I：

10.1002/jlcr.2984

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

[C-14]Formaldehyde was synthesized by reducing (CO2)-C-14 at ambient temperature with Schwartz's reagent. The [C-14]formaldehyde was then used in the radiosynthesis of high specific activity (2.1 GBq/mmol) [C-14]hydrochlorothiazide via cyclization of 4-amino-5-chloro-1,3-benzenedisulfonamide.

引用

页码：499 / 500

页数：2

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