Synthesis of acyl[35S]sulfonamides: Coupling of high specific activity [35S]methane sulfonamide with acids and acid chlorides

被引：0
|
作者：
Wallace, Michael [1 ]
Allentoff, Alban J. [1 ]
Bonacorsi, Samuel, Jr. [1 ]
机构：
[1] Bristol Myers Squibb Co, Radiochem, Princeton, NJ 08543 USA
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2012年 / 55卷 / 13期
关键词：
35S]methanesulfonamide; 35S]methanesulfonyl chloride; acyl sulfonamide; ARYL;
D O I：
10.1002/jlcr.2974
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Direct coupling of high specific activity [35S]methanesulfonamide, generated from [35S]methanesulfonyl chloride and ammonia, with acids and acid chlorides afforded the corresponding [35S]acyl sulfonamides in excellent yields. Examples of high specific activity [35S]acyl sulfonamides were prepared containing functionality that can be further elaborated through carboncarbon or carbonnitrogen bond forming reactions.
引用
收藏
页码：474 / 476
页数：3
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