In sickness and in health: the widespread application of creatine supplementation

被引:117
|
作者
Gualano, Bruno [1 ]
Roschel, Hamilton [1 ]
Lancha, Antonio Herbert, Jr. [1 ]
Brightbill, Charles E. [2 ]
Rawson, Eric S. [2 ]
机构
[1] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
[2] Bloomsburg Univ Penn, Dept Exercise Sci, Bloomsburg, PA 17815 USA
基金
巴西圣保罗研究基金会;
关键词
Nutritional supplements; Exercise performance; Sports; Chronic diseases; AMYOTROPHIC-LATERAL-SCLEROSIS; BODY-COMPOSITION; EXERCISE PERFORMANCE; SPRINT PERFORMANCE; MUSCULAR STRENGTH; RENAL-FUNCTION; MONOHYDRATE; MUSCLE; TERM; INCREASES;
D O I
10.1007/s00726-011-1132-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
There is an extensive and still growing body of the literature supporting the efficacy of creatine (Cr) supplementation. In sports, creatine has been recognized as the most effective nutritional supplement in enhancing exercise tolerance, muscle strength and lean body mass. From a clinical perspective, the application of Cr supplementation is indeed exciting. Evidences of benefits from this supplement have been reported in a broad range of diseases, including myopathies, neurodegenerative disorders, cancer, rheumatic diseases, and type 2 diabetes. In addition, after hundreds of published studies and millions of exposures creatine supplementation maintains an excellent safety profile. Thus, we contend that the widespread application of this supplement may benefit athletes, elderly people and various patient populations. In this narrative review, we aimed to summarize both the ergogenic and therapeutic effects of Cr supplementation. Furthermore, we reviewed the impact of Cr supplementation on kidney function.
引用
收藏
页码:519 / 529
页数:11
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