E-cadherin acts as a positive regulator of the JAK-STAT signaling pathway during Drosophila oogenesis

被引:3
|
作者
Mallart, Charlotte [1 ]
Chalvet, Fabienne [1 ]
Netter, Sophie [2 ]
Torres, Alba Yurani [1 ,3 ]
Poidevin, Mickael [1 ]
Montagne, Jacques [1 ]
Pret, Anne-Marie [2 ]
Malartre, Marianne [1 ]
机构
[1] Univ Paris Saclay, Inst Integrat Biol Cell I2BC, CEA, CNRS, Gif Sur Yvette, France
[2] Univ Paris Saclay, Inst Integrat Biol Cell I2BC, UVSQ, CEA,CNRS, Gif Sur Yvette, France
[3] Univ Calif Santa Barbara, Mol Cellular & Dev Biol Dept, Santa Barbara, CA USA
关键词
JAK-STAT; signaling; oogenesis; E-cadherin; morphogenesis; apoptosis; BORDER CELL-MIGRATION; JAK/STAT PATHWAY; DE-CADHERIN; FEEDBACK INHIBITION; ADHESION; DIFFERENTIATION; LOCALIZATION; ACTIVATION; AXIS;
D O I
10.3389/fcell.2022.886312
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The JAK-STAT pathway is evolutionary conserved. The simplicity of this signaling in Drosophila, due to the limited redundancy between pathway components, makes it an ideal model for investigation. In the Drosophila follicular epithelium, highly stereotyped functions of JAK-STAT signaling have been well characterized, but how signaling activity is regulated precisely to allow the different outcomes is not well understood. In this tissue, the ligand is secreted by the polar cells positioned at each follicle extremity, thus generating a gradient of JAK-STAT activity in adjacent cells. One way to control the delivered quantity of ligand is by regulating the number of polar cells, which is reduced by apoptosis to exactly two at each pole by mid-oogenesis. Hence, JAK-STAT activity is described as symmetrical between follicle anterior and posterior regions. Here, we show that JAK-STAT signaling activity is actually highly dynamic, resulting in asymmetry between poles by mid-oogenesis. Interestingly, we found similar temporal dynamics at follicle poles in the accumulation of the adherens junction E-cadherin protein. Remarkably, E-cadherin and JAK-STAT signaling not only display patterning overlaps but also share functions during oogenesis. In particular, we show that E-cadherin, like JAK-STAT signaling, regulates polar cell apoptosis non-cell-autonomously from follicle cells. Finally, our work reveals that E-cadherin is required for optimal JAK-STAT activity throughout oogenesis and that E-cadherin and Stat92E, the transcription factor of the pathway, form part of a physical complex in follicle cells. Taken together, our study establishes E-cadherin as a new positive regulator of JAK-STAT signaling during oogenesis.
引用
收藏
页数:13
相关论文
共 50 条
  • [31] Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
    Xue, Chen
    Yao, Qinfan
    Gu, Xinyu
    Shi, Qingmiao
    Yuan, Xin
    Chu, Qingfei
    Bao, Zhengyi
    Lu, Juan
    Li, Lanjuan
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 8 (01)
  • [32] JAK-STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review
    Huang, I-Hsin
    Chung, Wen-Hung
    Wu, Po-Chien
    Chen, Chun-Bing
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [33] Robustness analysis of the IFN-γ induced JAK-STAT signaling pathway
    Department of Biological Sciences and Biotechnology, Institute of Bioinformatics and Systems Biology, Tsinghua University, Beijing 100084, China
    不详
    不详
    1600, 491-495 (July 2005):
  • [34] Feifukang ameliorates pulmonary fibrosis by inhibiting JAK-STAT signaling pathway
    Hongbo Li
    Zhenkai Wang
    Jie Zhang
    Youlei Wang
    Chen Yu
    Jinjin Zhang
    Xiaodong Song
    Changjun Lv
    BMC Complementary and Alternative Medicine, 18
  • [35] Robustness analysis of the IFN-γ induced JAK-STAT signaling pathway
    Zi, ZK
    Sun, ZR
    JOURNAL OF COMPUTER SCIENCE AND TECHNOLOGY, 2005, 20 (04) : 491 - 495
  • [36] Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
    Chen Xue
    Qinfan Yao
    Xinyu Gu
    Qingmiao Shi
    Xin Yuan
    Qingfei Chu
    Zhengyi Bao
    Juan Lu
    Lanjuan Li
    Signal Transduction and Targeted Therapy, 8
  • [37] Robustness Analysis of the IFN-γ Induced JAK-STAT Signaling Pathway
    Zhi-Ke Zi
    Zhi-Rong Sun
    Journal of Computer Science and Technology, 2005, 20 : 491 - 495
  • [38] Fer kinase is a novel regulator of Jak/STAT signaling pathway
    Birch, Simone E.
    Tawadros, Patrick
    Szaszi, Katalin
    Kapus, Andras
    Rotstein, Ori D.
    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2006, 203 (03) : S27 - S28
  • [39] A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling
    Classen, Anne-Kathrin
    Bunker, Brandon D.
    Harvey, Kieran F.
    Vaccari, Thomas
    Bilder, David
    NATURE GENETICS, 2009, 41 (10) : 1150 - U139
  • [40] A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling
    Anne-Kathrin Classen
    Brandon D Bunker
    Kieran F Harvey
    Thomas Vaccari
    David Bilder
    Nature Genetics, 2009, 41 : 1150 - 1155