DNA topoisomerase IIβ: A player in regulation of gene expression and cell differentiation

被引：14
|
作者：
Vavrova, Anna [1 ]
Simunek, Tomas [1 ]
机构：
[1] Charles Univ Prague, Fac Pharm Hradec Kralove, Hradec Kralove 50005, Czech Republic
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2012年 / 44卷 / 06期
关键词：
Topoisomerase II beta; Topoisomerase II inhibitors; Gene expression; Cell cycle; DOUBLE-STRAND BREAKS; POLY(ADP-RIBOSE) POLYMERASE; LUNG-CANCER; ALPHA; CHEMOTHERAPY; NEURONS; REPAIR; XK469; FORMS;
D O I：
10.1016/j.biocel.2012.03.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
DNA topoisomerases II regulate conformational changes in DNA topology. They act on double-stranded DNA, catalyzing its relaxation, decatenation and unknotting. Vertebrate cells express two isoforms of topoisomerase II, which are similar in structure, but different in function and regulation. Whereas the alpha isoform is indispensable for proper cell replication, the functions of the beta isoform as well as reasons for its evolution in vertebrates were long unclear. Unlike topoisomerase II alpha, the beta isoform is predominantly expressed in quiescent cells and has been implicated mainly in the process of gene transcription. Recently, new discoveries point on the role of the topoisomerase II beta in regulation of cellular differentiation and tissue development. Furthermore, contemporary discoveries are raising possibilities for novel therapeutic approaches involving selective targeting of either topoisomerase II isoform in potentiating antitumor and/or reducing adverse effects of topoisomerase II poisons. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：834 / 837
页数：4
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