Ligand-Independent Mechanisms of Notch Activity

被引：67
|
作者：
Palmer, William Hunt [1 ]
Deng, Wu-Min [1 ]
机构：
[1] Florida State Univ, Dept Biol Sci, Tallahassee, FL 32306 USA
来源：
TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 11期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
SPLIT COMPLEX GENES; OF-DELTEX GENE; ESCRT-II; ENDOCYTIC TRAFFICKING; ENDOSOMAL TRAFFICKING; PROTEOLYTIC CLEAVAGE; SIGNALING PATHWAY; DROSOPHILA DELTEX; DOWN-REGULATION; CIS-INHIBITION;
D O I：
10.1016/j.tcb.2015.07.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Interaction between the Notch receptor and Delta-Serrate-Lag2 (DSL) ligands is generally deemed to be the starting point of the Notch signaling cascade, after which, Notch is cleaved and the intracellular domain acts as a transcriptional coactivator. By contrast, Notch protein can become activated independent of ligand stimulus through recently identified endosomal trafficking routes as well as through aberrant regulation of Notch components during Notch trafficking, ubiquitination, and degradation. In this review, we summarize genes implicated in ligand-independent Notch activity and remark on the mechanisms by which this process could occur.
引用
收藏
页码：697 / 707
页数：11
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