Preclinical evaluation of XPO1 inhibition in Wilms tumors.

被引:0
|
作者
Ortiz, Michael Vincent
Siddiquee, Armaan
You, Daoqi
Mundi, Prabhjot Singh
Marks, Lianna Q.
Guillan, Kristina
Diolaiti, Daniel
Aburi, Mahalaxmi
Califano, Andrea
Dela Cruz, Filemon S.
Kung, Andrew
机构
[1] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
[2] Columbia Univ, Med Ctr, New York, NY USA
[3] Stanford Univ, Palo Alto, CA 94304 USA
[4] Columbia Univ, New York, NY USA
基金
美国国家卫生研究院;
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3580
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Deconstructing protein and gene expression pathways to define the anticancer effects of XPO1 inhibition in ovarian cancer
    Evans, Brad R.
    Silvers, Thomas R.
    Chen, Ying A.
    Garcia, Jason
    Camacho, Catalina
    Sharp, Andrew J.
    Garag, Paras
    Koduru, Srinivas V.
    Billaud, Jean-Noel
    Halpert, Richard L.
    Dottino, Peter R.
    Landesman, Yosef
    Shacham, Sharon
    Martignetti, John A.
    CANCER RESEARCH, 2015, 75
  • [42] Inhibition of XPO1 impairs cholangiocarcinoma cell proliferation by triggering p53 intranuclear accumulation
    Zhao, Cheng
    Ma, Ben
    Yang, Zi-yi
    Li, Ou
    Liu, Shi-lei
    Pan, Li-jia
    Gong, Wei
    Dong, Ping
    Shu, Yi-jun
    CANCER MEDICINE, 2023, 12 (05): : 5751 - 5763
  • [43] XPO1 Inhibition Disrupts Ribosomal Subunits Assembly and Induces Multiple Myeloma (MM) Cell Death
    Tagoug, Ines
    Neri, Paola
    Slaby, Jiri
    Babich, Jacquelyn
    Simms, Justin
    Gratton, Kathy
    Ren, Li
    Bahlis, Nizar J.
    BLOOD, 2013, 122 (21)
  • [44] Inhibition of exportin 1 (XPO1) by selinexor (KPT-330) synergistically suppresses growth of neuroblastoma in combination with doxorubicin or bromodomain inhibition
    Ranieri, Pietro J.
    Trillo, Rebecca
    Landesman, Yosef
    Senapedis, William
    McCauley, Dilara
    Shacham, Sharon
    Kauffman, Michael
    Maris, John M.
    Attiyeh, Edward F.
    CANCER RESEARCH, 2015, 75
  • [45] XPO1 Inhibition Preferentially Disrupts the 3D Nuclear Organization of Telomeres in Tumor Cells
    Taylor-Kashton, Cheryl
    Lichtensztejn, Daniel
    Baloglu, Erkan
    Senapedis, William
    Shacham, Sharon
    Kauffman, Michael G.
    Kotb, Rami
    Mai, Sabine
    JOURNAL OF CELLULAR PHYSIOLOGY, 2016, 231 (12) : 2711 - 2719
  • [46] Discovery, Validation and Mechanistic Study of XPO1 Inhibition in the Treatment of Triple-Negative Breast Cancer
    Paulson, Amy L.
    Gruener, Robert F.
    Lee, Adam M.
    Huang, R. Stephanie
    CANCERS, 2024, 16 (23)
  • [47] Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer
    Chen, Ying
    Camacho, Sandra Catalina
    Silvers, Thomas R.
    Razak, Albiruni R. A.
    Gabrail, Nashat Y.
    Gerecitano, John F.
    Kalir, Eva
    Pereira, Elena
    Evans, Brad R.
    Ramus, Susan J.
    Huang, Fei
    Priedigkeit, Nolan
    Rodriguez, Estefania
    Donovan, Michael
    Khan, Faisal
    Kalir, Tamara
    Sebra, Robert
    Uzilov, Andrew
    Chen, Rong
    Sinha, Rileen
    Halpert, Richard
    Billaud, Jean-Noel
    Shacham, Sharon
    McCauley, Dilara
    Landesman, Yosef
    Rashal, Tami
    Kauffman, Michael
    Mirza, Mansoor R.
    Mau-Sorensen, Morten
    Dottino, Peter
    Martignetti, John A.
    CLINICAL CANCER RESEARCH, 2017, 23 (06) : 1552 - 1563
  • [48] Use of selective inhibition of nuclear export (SINE) using a CRM1/XPO1 antagonist to overcome resistance to CPT-11 in colon cancer in preclinical models
    Chung, Hye Won
    Fragomeni, Roberto A. Salas
    Shacham, Sharon
    Kauffman, Michael
    Cusack, James C.
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (04)
  • [49] Hitting a moving target: inhibition of the nuclear export receptor XPO1/CRM1 as a therapeutic approach in cancer
    Sendino, Maria
    Josu Omaetxebarria, Miren
    Antonio Rodriguez, Jose
    CANCER DRUG RESISTANCE, 2018, 1 (03) : 139 - 163
  • [50] XPO1 is selinexor prime target: validation by mutating cysteine 528 on both XPO1 alleles using CRISPR/Cas9 genome editing
    Neggers, Jasper E.
    Vercruysse, Thomas
    Jacquemyn, Maarten
    Vanstreels, Els
    Baloglu, Erkan
    Shacham, Sharon
    Crochiere, Marsha
    Senapedis, William
    Landesman, Yosef
    Daelemans, Dirk
    CANCER RESEARCH, 2015, 75