Extracellular ATP inhibits Schwann cell dedifferentiation and proliferation in an ex vivo model of Wallerian degeneration

被引：19

作者：

Shin, Youn Ho ^{[1
]}

Lee, Seo Jin ^{[1
]}

Jung, Junyang ^{[1
]}

机构：

[1] Kyung Hee Univ, Dept Anat, Coll Med, Seoul 130701, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2013年 / 430卷 / 02期

关键词：

ATP; Schwann cell; Lysosomal exocytosis; Dedifferentiation; Proliferation; Wallerian degeneration; SCIATIC-NERVE TRANSECTION; NEGATIVE REGULATOR; SIGNALING PATHWAY; P38; MAPK; IN-VITRO; MYELINATION; EXPRESSION; RECEPTOR; ACTIVATION; ADENOSINE;

D O I：

10.1016/j.bbrc.2012.11.057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

After nerve injury, Schwann cells proliferate and revert to a phenotype that supports nerve regeneration. This phenotype-changing process can be viewed as Schwann cell dedifferentiation. Here, we investigated the role of extracellular ATP in Schwann cell dedifferentiation and proliferation during Wallerian degeneration. Using several markers of Schwann cell dedifferentiation and proliferation in sciatic explants, we found that extracellular ATP inhibits Schwann cell dedifferentiation and proliferation during Wallerian degeneration. Furthermore, the blockage of lysosomal exocytosis in ATP-treated sciatic explants is sufficient to induce Schwann cell dedifferentiation. Together, these findings suggest that ATP-induced lysosomal exocytosis may be involved in Schwann cell dedifferentiation. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：852 / 857

页数：6

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