Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses

被引：158
|
作者：
van de Sandt, Carolien E. [1 ]
Kreijtz, Joost H. C. M. [1 ]
Rimmelzwaan, Guus F. [1 ]
机构：
[1] ErasmusMC, Dept Virol, NL-3015 GE Rotterdam, Netherlands
来源：
VIRUSES-BASEL | 2012年 / 4卷 / 09期
关键词：
influenza; evasion; innate immunity; adaptive immunity; CYTOTOXIC-T-LYMPHOCYTE; RESPIRATORY SYNCYTIAL VIRUS; CROSS-PROTECTIVE IMMUNITY; CELL-MEDIATED PROTECTION; AMINO-ACID SUBSTITUTION; TUMOR-NECROSIS-FACTOR; NATURAL-KILLER-CELLS; TOLL-LIKE RECEPTORS; DOUBLE-STRANDED-RNA; PRE-MESSENGER-RNAS;
D O I：
10.3390/v4091438
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The influenza A virus is one of the leading causes of respiratory tract infections in humans. Upon infection with an influenza A virus, both innate and adaptive immune responses are induced. Here we discuss various strategies used by influenza A viruses to evade innate immune responses and recognition by components of the humoral and cellular immune response, which consequently may result in reduced clearing of the virus and virus-infected cells. Finally, we discuss how the current knowledge about immune evasion can be used to improve influenza A vaccination strategies.
引用
收藏
页码：1438 / 1476
页数：39
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