Solubility of esomeprazole magnesium trihydrate in alcohols at temperatures from 298.15 to 318.15 K

被引：4

作者：

Bhesaniya, K. ^{[1
]}

Baluja, S. ^{[1
]}

机构：

[1] Saurashtra Univ, Dept Chem, Phys Chem Lab, Rajkot 360005, Gujarat, India

来源：

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A | 2013年 / 87卷 / 13期

关键词：

esomeprazole magnesium trihydrate; solubility; thermodynamic properties; ENTHALPY-ENTROPY COMPENSATION; PROTON-PUMP; ACID; WATER; OMEPRAZOLE; DISORDERS; MIXTURES;

D O I：

10.1134/S0036024413130062

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The solubility of esomeprazole magnesium trihydrate in methanol, ethanol, 1-propanol and 1-butanol was determined at temperatures ranging from 298.15 to 318.15 K at atmospheric pressure using gravimetrical method. The highest solubility is found in 1-butanol and lowest in ethanol. The experimental solubility data are correlated by the modified Apelblat equation. Thermodynamic properties such as dissolution enthalpy, Gibb's energy, and entropy of mixing have been determined from the solubility data.

引用

页码：2187 / 2190

页数：4

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