Pre-hospital first aid is the forefront of emergency medical service, which is increasingly valued by medical workers. Pre-hospital first aid is a developing, challenging, and rewarding area of clinical practice. With development of first-aid service, pre-hospital first aid has received more and more attention. In order to improve the public's first-aid awareness, it is necessary to analyze the disease spectrum and epidemiological changes of pre-hospital first aid. In the past five years, the number of pre-hospital emergencies has been increasing over year, with two small peaks at 20 similar to 29 years and 80 similar to 89 years respectively. The ratio of male to female was 1.33: 1. In terms of disease spectrum, trauma has always been in first place. In the distribution of first aid call time, pre-hospital emergency patients' crying peak period was from 08: 00 to 11: 00 am, with 8: 00 to 9: 00 am being the peak. Through the analysis of disease spectrum and epidemiological changes of pre-hospital first aid, it is helpful to adjust and strengthen emergency resources, so as to improve the emergency response capability.