The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission

被引：0

作者：

McKinnon, Lyle R. ^{[1
,2
]}

Achilles, Sharon L. ^{[3
,4
]}

Bradshaw, Catriona S. ^{[5
,6
]}

Burgener, Adam ^{[7
,8
,9
,10
]}

Crucitti, Tania ^{[11
]}

Fredricks, David N. ^{[12
,13
]}

Jaspan, Heather B. ^{[14
,15
,16
]}

Kaul, Rupert ^{[17
,18
]}

Kaushic, Charu ^{[19
,20
]}

Klatt, Nichole ^{[21
]}

Kwon, Douglas S. ^{[22
,23
,24
]}

Marrazzo, Jeanne M. ^{[25
]}

Masson, Lindi ^{[26
,27
]}

McClelland, R. Scott ^{[13
,28
,29
]}

Ravel, Jacques ^{[30
,31
]}

van de Wijgert, Janneke H. H. M. ^{[32
,33
]}

Vodstrcil, Lenka A. ^{[5
,6
]}

Tachedjian, Gilda ^{[34
,35
,36
,37
]}

机构：

[1] Univ Manitoba, Dept Med Microbiol & Infect Dis, Room 504,745 Bannatyne Ave, Winnipeg, MB R3E 0J9, Canada

[2] Ctr AIDS Programme Res South Africa, Durban, South Africa

[3] Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA

[4] Magee Womens Res Inst, Pittsburgh, PA USA

[5] Monash Univ, Cent Clin Sch, Melbourne, Vic, Australia

[6] Alfred Hosp, Melbourne Sexual Hlth Ctr, Carlton, Vic, Australia

[7] Publ Hlth Agcy Canada, Natl HIV & Retrovirol Labs, Winnipeg, MB, Canada

[8] Univ Manitoba, Dept Obstet & Gynecol, Winnipeg, MB, Canada

[9] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada

[10] Karolinska Inst, Dept Med Solna, Stockholm, Sweden

[11] Ctr Pasteur Cameroun, Yaounde, Cameroon

[12] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis, 1124 Columbia St, Seattle, WA 98104 USA

[13] Univ Washington, Dept Med, Seattle, WA USA

[14] Seattle Childrens Res Inst, Seattle, WA USA

[15] Univ Washington, Seattle, WA 98195 USA

[16] Univ Cape Town, Inst Infect Dis & Mol Med, Dept Pathol, Div Immunol, Cape Town, South Africa

[17] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[18] Univ Toronto, Dept Med, Toronto, ON, Canada

[19] McMaster Univ, McMaster Immunol Res Ctr, Michael G DeGroote Ctr Learning & Discovery, Hamilton, ON, Canada

[20] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada

[21] Univ Miami, Dept Pediat, Miami, FL 33152 USA

[22] MIT, Ragon Inst MGH, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[23] Massachusetts Gen Hosp, Cambridge, MA USA

[24] Harvard Med Sch, Boston, MA 02115 USA

[25] Univ Alabama Birmingham, Div Infect Dis, Birmingham, AL USA

[26] Univ Cape Town, Div Med Virol, Inst Infect Dis & Mol Med, Cape Town, South Africa

[27] Univ Cape Town, Ctr AIDS HIV Program Res South Africa CAPRISA, Ctr Excellence, Cape Town, South Africa

[28] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[29] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[30] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA

[31] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

[32] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[33] Univ Liverpool, Inst Infect & Global Hlth, Liverpool, Merseyside, England

[34] Burnet Inst, Life Sci Discipline, Dis Eliminat Program, 85 Commercial Rd, Melbourne, Vic 3004, Australia

[35] Monash Univ, Dept Microbiol, Clayton, Vic, Australia

[36] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia

[37] RMIT Univ, Coll Sci Engn & Hlth, Sch Sci, Melbourne, Vic, Australia

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2019年 / 35卷 / 03期

基金：

加拿大健康研究院; 英国医学研究理事会; 美国国家卫生研究院;

关键词：

HIV; vaginal microbiota; bacterial vaginosis; HIV transmission; genital inflammation; female reproductive tract; MOLECULAR VAGINAL MICROBIOTA; INFLAMMATORY CYTOKINES; AFRICAN WOMEN; ACQUISITION; TRACT; RISK; HEALTH;

D O I：

10.1089/aid.2018.0304

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacterial vaginosis (BV) is a common yet poorly understood vaginal condition that has become a major focus of HIV transmission and immunology research. Varied terminologies are used by clinicians and researchers to describe microbial communities that reside in the female reproductive tract (FRT), which is driven, in part, by microbial genetic and metabolic complexity, evolving diagnostic and molecular techniques, and multidisciplinary perspectives of clinicians, epidemiologists, microbiologists, and immunologists who all appreciate the scientific importance of understanding mechanisms that underlie BV. This Perspectives article aims to clarify the varied terms used to describe the cervicovaginal microbiota and its nonoptimal state, under the overarching term of BV. The ultimate goal is to move toward language standardization in future literature that facilitates a better understanding of the impact of BV on FRT immunology and risk of sexually transmitted infections, including HIV.

引用

页码：219 / 228

页数：10

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