Frajunolides E-K, briarane diterpenes from Junceella fragilis

被引：37
|
作者：
Liaw, Chia-Ching [2 ]
Shen, Ya-Ching [1 ]
Lin, Yun-Sheng [2 ]
Hwang, Tsong-Long [3 ]
Kuo, Yao-Haur [4 ]
Khalil, Ashraf Taha [1 ]
机构：
[1] Natl Taiwan Univ, Sch Pharm, Coll Med, Taipei 100, Taiwan
[2] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan
[3] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan
[4] Natl Res Inst Chinese Med, Taipei 112, Taiwan
来源：
JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 09期
关键词：
D O I：
10.1021/np800126f
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Chemical investigation of the gorgonian octocoral Junceella fragilis, collected in Taiwan, resulted in the isolation of seven new briarane-type diterpenes, frajunolides E-K (1-7), in addition to 14 known briaranes, praelolide, junceellin, junceellolides A-E, and K, 11a,20a-epoxy-4-deacetoxyjunceelolide D, umbraculolide A, junceellonoid A, and juncins Y, Z, and ZI, as well as ergosterol peroxide. The structures of 1-7 were determined by analysis of HRESIMS and 2D NMR spectroscopic data. Cytotoxicity and in vitro anti-inflammatory activities of compounds 1-7 were also evaluated.
引用
收藏
页码：1551 / 1556
页数：6
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