Rheumatoid arthritis (RA) is a chronic symmetrical autoimmune disease of unknown etiology that affects primarily the diarthrodial joints. Characteristic features of RA pathogenesis are synovial inflammation and proliferation accompanied by cartilage erosion and bone loss. Fibroblast-like synoviocytes (FLS) display an important role in the pathogenesis of RA. Several lines of evidence show that the Wnt signaling pathway significantly participates in the RA pathogenesis. The Wnt proteins are glycoproteins that bind to the Fz receptors on the cell surface, which leads to several important biological functions, such as cell differentiation, embryonic development limb development and joint formation. Accumulated evidence has suggested that this signaling pathway plays a key role in the FLS activation, bone resorption and joint destruction during RA development. Greater knowledge of the role of the Wnt signaling pathway in RA could improve understanding of the RA pathogenesis and the differences in RA clinical presentation and prognosis. In this review, new advances of the Wnt signaling pathway in RA pathogenesis are discussed, with special emphasis on its different roles in synovial inflammation and bone remodeling. Further studies are needed to reveal the important role of the members of the Wnt signaling pathway in the RA pathogenesis and treatment (C) 2013 Elsevier Inc. All rights reserved.
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Palo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
Stanford Univ, Dept Med, Stanford, CA 94305 USAPalo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
Ye, Zhongde
Shen, Yi
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Stanford Univ, Dept Med, Stanford, CA 94305 USAPalo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
Shen, Yi
Jin, Ke
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Stanford Univ, Dept Med, Stanford, CA 94305 USAPalo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
Jin, Ke
Qiu, Jingtao
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Stanford Univ, Dept Med, Stanford, CA 94305 USAPalo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
Qiu, Jingtao
Hu, Bin
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Palo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
Stanford Univ, Dept Med, Stanford, CA 94305 USAPalo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
Hu, Bin
Jadhav, Rohit R.
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Palo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
Stanford Univ, Dept Med, Stanford, CA 94305 USAPalo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
Jadhav, Rohit R.
Sheth, Khushboo
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Palo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USAPalo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
Sheth, Khushboo
Weyand, Cornelia M.
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Palo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
Stanford Univ, Dept Med, Stanford, CA 94305 USAPalo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
Weyand, Cornelia M.
Goronzy, Jorg J.
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Palo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
Stanford Univ, Dept Med, Stanford, CA 94305 USAPalo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA
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Zunyi Med & Pharmaceut Coll, Tradit Chinese Med Dept, Zunyi 563006, Guizhou, Peoples R ChinaZunyi Med & Pharmaceut Coll, Tradit Chinese Med Dept, Zunyi 563006, Guizhou, Peoples R China
Dong, Xiaojun
Gan, Yuan
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Zunyi Med & Pharmaceut Coll, Tradit Chinese Med Dept, Zunyi 563006, Guizhou, Peoples R ChinaZunyi Med & Pharmaceut Coll, Tradit Chinese Med Dept, Zunyi 563006, Guizhou, Peoples R China
Gan, Yuan
Ding, Lina
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Zunyi Med & Pharmaceut Coll, Tradit Chinese Med Dept, Zunyi 563006, Guizhou, Peoples R ChinaZunyi Med & Pharmaceut Coll, Tradit Chinese Med Dept, Zunyi 563006, Guizhou, Peoples R China
Ding, Lina
Zeng, Fujia
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Zunyi Med & Pharmaceut Coll, Tradit Chinese Med Dept, Zunyi 563006, Guizhou, Peoples R ChinaZunyi Med & Pharmaceut Coll, Tradit Chinese Med Dept, Zunyi 563006, Guizhou, Peoples R China
Zeng, Fujia
Ding, Dou
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Zunyi Med & Pharmaceut Coll, Tradit Chinese Med Dept, Zunyi 563006, Guizhou, Peoples R ChinaZunyi Med & Pharmaceut Coll, Tradit Chinese Med Dept, Zunyi 563006, Guizhou, Peoples R China
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Changchun Univ Chinese Med, Coll Integrat Med, Changchun, Jilin, Peoples R ChinaChangchun Univ Chinese Med, Coll Integrat Med, Changchun, Jilin, Peoples R China
Jiang, Xin
He, Yanxin
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Changchun Univ Chinese Med, Jilin Ginseng Acad, Changchun, Jilin, Peoples R ChinaChangchun Univ Chinese Med, Coll Integrat Med, Changchun, Jilin, Peoples R China
He, Yanxin
Zhao, Ying
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Changchun Univ Chinese Med, Coll Integrat Med, Changchun, Jilin, Peoples R ChinaChangchun Univ Chinese Med, Coll Integrat Med, Changchun, Jilin, Peoples R China
Zhao, Ying
Pan, Zhi
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Changchun Univ Chinese Med, Jilin Ginseng Acad, Changchun, Jilin, Peoples R ChinaChangchun Univ Chinese Med, Coll Integrat Med, Changchun, Jilin, Peoples R China
Pan, Zhi
Wang, Yinghang
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Changchun Univ Chinese Med, Affiliated Hosp, Changchun, Jilin, Peoples R ChinaChangchun Univ Chinese Med, Coll Integrat Med, Changchun, Jilin, Peoples R China