Netherton syndrome: Temporary response to dupilumab

被引：30

作者：

Aktas, Meryem ^{[1
]}

Salman, Andac ^{[1
]}

Apti Sengun, Ozlem ^{[1
]}

Comert Ozer, Elif ^{[1
]}

Hosgoren Tekin, Selcen ^{[1
]}

Akin Cakici, Ozlem ^{[1
]}

Demir, Gizem ^{[1
]}

Ergun, Tulin ^{[1
]}

机构：

[1] Marmara Univ, Sch Med, Dept Dermatol, Istanbul, Turkey

来源：

PEDIATRIC DERMATOLOGY | 2020年 / 37卷 / 06期

关键词：

atopic eczema; genetic diseases; mechanisms; Ichthyosis;

D O I：

10.1111/pde.14362

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Netherton syndrome (NS) is an orphan disease characterized by congenital ichthyosis, hair abnormalities, and atopy, with limited treatment options. We achieved temporary improvement only during the initial 6 weeks of treatment with dupilumab, which differs from the sustained improvement observed in 2 other recently published cases. Although the clinical presentation of atopy and increased pre-allergic cytokines in NS patients suggest that dupilumab may be beneficial, larger studies are required.

引用

页码：1210 / 1211

页数：2

共 50 条

[31] NETHERTON SYNDROME
DUPERRAT, B
PUISSANT, A
BLANCHETBARDON, C
HOMAREAU, S
DELANOE, J
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, 1977, 104 (8-9): : 568 - 569
[32] Netherton syndrome
Harries, MJ
Judge, MR
BRITISH JOURNAL OF DERMATOLOGY, 2005, 153 (02) : 470 - 470
[33] Dupilumab improves clinical symptoms in children with Netherton syndrome by suppressing Th2-mediated inflammation
Yan, Shi
Wu, Xuege
Jiang, Jinqiu
Yu, Shijuan
Fang, Xiao
Yang, Huan
Bai, Xiaoming
Wang, Hua
Luo, Xiaoyan
FRONTIERS IN IMMUNOLOGY, 2022, 13
[34] Successful treatment of Netherton syndrome with dupilumab implicates a role for Th2 signaling in this type of ichthyosis
Blunder, S.
Schmuth, M.
Gruber, R.
EXPERIMENTAL DERMATOLOGY, 2022, 31 (02) : E30 - E30
[35] WHAT SYNDROME IS THIS - NETHERTON SYNDROME
KRAFCHIK, BR
PEDIATRIC DERMATOLOGY, 1992, 9 (02) : 157 - 160
[36] NETHERTON-SYNDROME
ORFANOS, CE
MAHRLE, G
SALAMON, T
HAUTARZT, 1971, 22 (09): : 397 - &
[37] Hypothyroidism in Netherton syndrome
Garty, Ben Zion
Nimri, Revital
PEDIATRIC DERMATOLOGY, 2008, 25 (01) : 134 - 135
[38] Long-term dupilumab therapy in Netherton syndrome with severe atopic manifestations: Case report and review of the literature
Ozkaya, Esen
Gunay, Muhammed Burak
Babuna Kobaner, Goncagul
Keskinkaya, Zeynep
Gokalp, Mehmet Onur
AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2023, 64 (02) : 272 - 277
[39] Netherton's syndrome
Brzezinska-Wcislo, L
Kaminska-Budzinska, G
Macura-Gina, M
Krauze, E
Trzmiel, D
Bergler-Czop, B
SKIN AND ENVIRONMENT - PERCEPTION AND PROTECTION, VOLS 1 AND 2, 2001, : 7 - 11
[40] NETHERTON SYNDROME REVISITED
SERALY, MP
SHEEHAN, M
COLLINS, M
MOSTOW, E
PEDIATRIC DERMATOLOGY, 1994, 11 (01) : 61 - 64

← 1 2 3 4 5 →