THIOREDOXIN AND THIOREDOXIN REDUCTASE IN THE PATHOGENESIS OF SELECTED HUMAN DISEASES, PART II

被引:0
|
作者
Popielarski, Marcin [1 ]
Ponamarczuk, Halszka [1 ]
Kusinska, Katarzyna [1 ]
Swiatkowska, Maria [1 ]
机构
[1] Uniwersytet Med & Lodzi, Zaklad Cytobiol & Prote, Katedra Nauk Biomed, Ul Mazowiecka 6-8, PL-92215 Lodz, Poland
关键词
thioredoxin; thioredoxin reductase; cancers; oxidative stress; apoptosis; CANCER-CELL-GROWTH; 1-METHYLPROPYL 2-IMIDAZOLYL DISULFIDE; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; MITOCHONDRIAL COMPLEX-III; MAMMALIAN THIOREDOXIN; ARSENIC TRIOXIDE; ORGANOTELLURIUM COMPOUNDS; MOTEXAFIN GADOLINIUM; MOLECULAR-MECHANISMS; GOLD(I) COMPLEXES;
D O I
暂无
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Thioredoxin and thioredoxin reductase form a thioredoxin system, which is involved in protecting cells against oxidative stress, regulation of apoptosis and regulation of tumorigenesis. Defects in thioredoxin system are associated with the pathogenesis of many human diseases, including the development of cancer. Overexpression of thioredoxin and thioredoxin reductase leads to increased proliferation, angiogenesis and initiation of anti-apoptotic pathways. Increased levels of thioredoxin and thioredoxin reductase are considered to be one of the mechanisms correlated with drug resistance in malignant cells. We can observe growing evidences suggesting the role of thioredoxin and thioredoxin reductase inhibitors in treatment of tumors. Results of therapy using thioredoxin and thioredoxin reductase inhibitors seems to be very promising.
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页码:159 / 179
页数:21
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