Real-Time Detection of Circulating Tumor Cells in Living Animals Using Functionalized Large Gold Nanorods

被引：20

作者：

Dutta, Rebecca ^{[1
,2
,3
]}

Liba, Orly ^{[1
,2
,3
,4
]}

SoRelle, Elliott D. ^{[1
,2
,3
,5
]}

Winetraub, Yonatan ^{[1
,2
,3
,5
]}

Ramani, Vishnu C. ^{[6
]}

Jeffrey, Stefanie S. ^{[6
]}

Sledge, George W. ^{[7
]}

de la Zerda, Adam ^{[1
,2
,3
,4
,5
,8
]}

机构：

[1] Stanford Univ, Dept Biol Struct, Stanford, CA 94305 USA

[2] Stanford Univ, Mol Imaging Program, Stanford, CA 94305 USA

[3] Stanford Univ, BioX Program, Stanford, CA 94305 USA

[4] Stanford Univ, Elect Engn, Stanford, CA 94305 USA

[5] Stanford Univ, Biophys Program, Stanford, CA 94305 USA

[6] Stanford Univ, Dept Surg, Sch Med, Stanford, CA 94305 USA

[7] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

[8] Chan Zuckerberg Biohub, San Francisco, CA 94158 USA

来源：

NANO LETTERS | 2019年 / 19卷 / 04期

基金：

美国国家科学基金会;

关键词：

Optical coherence tomography; circulating tumor cells; gold nanorods; HIGH-RESOLUTION; SPECKLE; CANCER;

D O I：

10.1021/acs.nanolett.8b05005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Optical coherence tomography (OCT) can be utilized with significant speckle reduction techniques and highly scattering contrast agents for non-invasive, contrast-enhanced imaging of living tissues at the cellular scale. The advantages of reduced speckle noise and improved targeted contrast can be harnessed to track objects as small as 2 mu m in vivo, which enables applications for cell tracking and quantification in living subjects. Here we demonstrate the use of large gold nanorods as contrast agents for detecting individual micron-sized polystyrene beads and single myeloma cells in blood circulation using speckle-modulating OCT. This report marks the first time that OCT has been used to detect individual cells within blood in vivo. This technical capability unlocks exciting opportunities for dynamic detection and quantification of tumor cells circulating in living subjects.

引用

页码：2334 / 2342

页数：9

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