A novel method to highly versatile monomeric PNA building blocks by multi component reactions

被引：29
|
作者：
Dömling, A
Chi, KZ
Barrère, M
机构：
[1] Morphochem AG, D-82152 Martinsried, Germany
[2] Tech Univ Munich, Inst Organ Chem & Biochem, D-85747 Garching, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 19期
关键词：
PNA; MCR; combinatorial chemistry; Ugi reaction;
D O I：
10.1016/S0960-894X(99)00491-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel approach to monomeric PNA building blocks by a solution phase Ugi multi component reaction (MCR) is described. The reaction is easily performed in 96 well plates. The products precipitate from the reaction solution and are thus obtained in high yields and purity. Those products are not amenable by another multi step synthesis in such a diversity. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2871 / 2874
页数：4
相关论文
共 50 条
  • [31] Catalytic silylation reactions: Organosilanes and organosilanols-environmentally benign, versatile synthetic building blocks, and synthetic targets
    Jeon, Junha
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [32] Carbon-11 labelled isocyanides: new versatile building blocks to access novel PET tracers
    Bonnemaire, Coralie
    Windhorst, Albert
    van der Aa, Frank
    Collet, Jurrien
    Roose, Tom
    Ruijter, Eelco
    Orru, Romano
    Vugts, Danielle
    NUCLEAR MEDICINE AND BIOLOGY, 2022, 108 : S27 - S28
  • [33] In situ generation of novel isonitriles and its application in building heterocyclic core structures via multi-component reactions
    Qiao, Lixin
    Zhang, Ying
    Yu, Libing
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [34] Expanding the Azaspiro[3.3]heptane Family: Synthesis of Novel Highly Functionalized Building Blocks
    Burkhard, Johannes A.
    Guerot, Carine
    Knust, Henner
    Carreira, Erick M.
    ORGANIC LETTERS, 2012, 14 (01) : 66 - 69
  • [35] Preparation of thioamide building blocks via microwave-promoted three-component Kindler reactions
    Zbruyev, OI
    Stiasni, N
    Kappe, CO
    JOURNAL OF COMBINATORIAL CHEMISTRY, 2003, 5 (02): : 145 - 148
  • [36] Synthesis and reactions of novel imidazo[4,5-b]pyridine building blocks
    Dubina, Tetiana F.
    Kosarevych, Anton V.
    Kucher, Olexandr V.
    Sosunovych, Bohdan S.
    Smolii, Oleg B.
    Vashchenko, Bohdan V.
    Grygorenko, Oleksandr O.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2024, : 175 - 182
  • [37] A Novel, Controllable, and Efficient Method for Building Highly Hydrophobic Aerogels
    Li, Shu-Liang
    Wang, Yu-Tao
    Zhang, Shi-Jun
    Sun, Mingze
    Li, Jie
    Chu, Li-Qiu
    Hu, Chen-Xi
    Huang, Yi-Lun
    Gao, Da-Li
    Schiraldi, David A.
    GELS, 2024, 10 (02)
  • [38] A Novel Image Compression Method Based on Classified Energy and Pattern Building Blocks
    Guz, Umit
    EURASIP JOURNAL ON ADVANCES IN SIGNAL PROCESSING, 2011,
  • [39] A Novel Image Compression Method Based on Classified Energy and Pattern Building Blocks
    Umit Guz
    EURASIP Journal on Advances in Signal Processing, 2011
  • [40] A Novel, Reliable and Highly Versatile Method to Evaluate Different Prion Decontamination Procedures
    Erana, Hasier
    Perez-Castro, Miguel Angel
    Garcia-Martinez, Sandra
    Charco, Jorge M.
    Lopez-Moreno, Rafael
    Diaz-Dominguez, Carlos M.
    Barrio, Tomas
    Gonzalez-Miranda, Ezequiel
    Castilla, Joaquin
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020, 8
12345