Organic Solvent Nanofiltration as a Tool for Separation of Quinine-Based Organocatalysts

被引：19

作者：

Fahrenwaldt, Thomas ^{[1
]}

Grosseheilmann, Julia ^{[1
]}

Erben, Friedrich ^{[2
]}

Kragl, Udo ^{[1
]}

机构：

[1] Univ Rostock, Inst Chem, D-18059 Rostock, Germany

[2] Leibniz Inst Catalysis LIKAT Rostock, D-18059 Rostock, Germany

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2013年 / 17卷 / 09期

关键词：

ASYMMETRIC MICHAEL ADDITION; CINCHONA ORGANOCATALYSTS; RESISTANT NANOFILTRATION; MEMBRANE REACTOR; CATALYSTS; EFFICIENT;

D O I：

10.1021/op400037h

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Organic solvent nanofiltration (OSN) promises to be a versatile tool for mild and energy-saving downstream processing. In this case study, the use of modern solvent-resistant membranes to separate organocatalysts from reaction media was investigated. Commercially available membranes with molecular weight cut-offs (MWCOs) between 150 and 500 g mol(-1) were used. They showed high rejections of up to 99% for native catalysts in THF. The enantioselective Henry reaction of ethyl pyruvate and nitromethane catalyzed by benzoyl cupreine was used to demonstrate the potential of this technique for preparative use.

引用

页码：1131 / 1136

页数：6

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