Fuzhengpaidu granule regulates immune activation molecules CD38 and human leukocyte antigen-D related on CD4+and CD8+T cells in patients with acquired immunodeficiency syndrome/human immunodeficiency virus

被引：8
|
作者：
Jiang, Feng [1 ]
Zhang, Rongxin [1 ]
Gu, Zhenfang [2 ]
Zhang, Huailing [2 ]
Guo, Huijun [2 ]
Deng, Xin [1 ]
Liang, Jian [1 ]
机构：
[1] Guangxi Univ Chinese Med, Ruikang Hosp Affiliated, AIDS Res Ctr, Nanning 530011, Peoples R China
[2] Henan Univ TCM, Affiliated Hosp 1, Clin Res Ctr, Zhengzhou 450000, Peoples R China
来源：
JOURNAL OF TRADITIONAL CHINESE MEDICINE | 2013年 / 33卷 / 04期
基金：
中国博士后科学基金;
关键词：
HIV; Acquired immunodeficiency syndrome; Fuzhengpaidu granule; Activated-leukocyte cell adhesion molecule; HLA-DR antigens; Immunocompetence;
D O I：
10.1016/S0254-6272(13)60145-4
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
OBJECTIVE: To evaluate the effect of Fuzhengpaidu granule (FZPDG) on immune activation molecules CD38 and human leukocyte antigen-D related (HLA-DR) on CD4+ and CD8+ cells in HIV/AIDS patients, and to explore the underlying mechanism of this therapy. METHODS: Plasma changes in CD3+, CD4+, CD8+, CD3+ CD4+ CD38+, CD3+CD4+HLA-DR+, CD3+ CD8+CD38+, and CD3+CD8+HLA-DR+ levels in HIV/AIDS patients treated with FZPDG for six months were examined by flow cytometry and compared with levels in healthy controls. RESULTS: The clinical trial included 34 outpatients with HIV/AIDS. Before treatment, plasma levels of CD38+ and HLA-DR+ on CD4/CD8 cells were higher than those in 28 health controls (P<0.05). There were no significant changes in serum levels of CD3+, CD4+, and CD8+ T cells between pretreatment baseline versus after treatment, which were 82.85% +/- 5.41%, 14.57% +/- 10.31% and 54.55% +/- 11.43% before treatment and 79.15% +/- 8.21%, 19.96% +/- 9.58% and 56.36% +/- 11.67% after treatment, respectively (P>0.05). Plasma levels of CD3+ CD4+CD38+ and CD3+CD4+HLA-DR+ were 2.3% 2.2% and 7.8% 5.5% before treatment and 1.2% +/- 0.8% and 2.6% +/- 1.0% after treatment, respectively. Plasma levels of CD3+CD8+CD38+ and CD3+CD8+HLA-DR+ were 41.4% +/- 13.4% and 17.8% +/- 11.3% before treatment, which changed to 27.1% +/- 10.2% and 3.8% +/- 2.4% after treatment, respectively (P<0.05). CONCLUSION: HIV/AIDS patients exhibited an immune activation profile following FZPDG treatment. A potential mechanism of action for FZPDG appears to lie in its ability to up-regulate CD38 and HLA-DR levels on CD4+ T cells, and down-regulate them on CD8+ cells, thereby modulating immune activation of CD4+ and CD8+T cells. (C) 2013 JTCM. All rights reserved.
引用
收藏
页码：439 / 443
页数：5
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