The proteasome and the degradation of oxidized proteins: Part I-structure of proteasomes

被引：77
|
作者：
Jung, Tobias [1 ]
Grune, Tilman [1 ]
机构：
[1] Univ Jena, Inst Nutr, Dept Nutr Toxicol, D-07743 Jena, Germany
来源：
REDOX BIOLOGY | 2013年 / 1卷 / 01期
关键词：
20S proteasome; 26S proteasome; Proteasomal regulators;
D O I：
10.1016/j.redox.2013.01.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The main machinery responsible for cellular protein maintenance is the ubiquitin-proteasomal system, with its core particle the 20S proteasome. The main task of the system is a fast and efficient degradation of proteins not needed anymore in cellular metabolism. For this aim a complex system of regulators evolved, modifying the function of the 20S core proteasome. Here we summarize shortly the structure of the 20S proteasome as well as its associated regulator proteins. (C) 2013 The Authors. Published by Elsevier By. Open access under CC BY-NC-ND license
引用
收藏
页码：178 / 182
页数：5
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