Synthesis of oligonucleotide conjugates with the aid of N-chloroacetamidohexyl phosphoramidite reagent

被引：1
|
作者：
Guzaev, A [1 ]
Manoharan, M [1 ]
机构：
[1] ISIS Pharmaceut, Dept Med Chem, Carlsbad, CA 92008 USA
来源：
NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 6-7期
关键词：
D O I：
10.1080/07328319908044750
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel phosphoramidite building block derived from N-chloroacetyl-6-aminohexanol is attached at the 5'-terminus on the last step of oligonucleotide synthesis. Postsynthetic treatment of support-bound modified oligonucleotides with a variety of amines and mercaptanes affords oligonucleotide conjugates in a high yield.
引用
收藏
页码：1455 / 1456
页数：2
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