Enantioselective Palladium(II) Phosphate Catalyzed Three-Component Reactions of Pyrrole, Diazoesters, and Imines

被引：128
|
作者：
Zhang, Dan [1 ]
Qiu, Huang [1 ]
Jiang, Liqin [1 ]
Lv, Fengping [1 ]
Ma, Chaoqun [1 ]
Hu, Wenhao [1 ]
机构：
[1] E China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 50期
关键词：
CH functionalization; heterocycles; multicomponent reactions; palladium; zwitterions; FRIEDEL-CRAFTS ALKYLATION; STEREOSELECTIVE CYCLOPROPANATION; CARBENE INSERTION; N-TOSYLHYDRAZONES; ALPHA-ALLYLATION; ALLYLIC ALCOHOLS; DIAZO-COMPOUNDS; ACID; INDOLES; FUNCTIONALIZATION;
D O I：
10.1002/anie.201306824
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reaction trio: The title reaction delivers CH functionalized pyrrole derivatives in moderate to good yields. This novel three-component reaction provides both syn- and anti-pyrrole derivatives having two contiguous stereocenters with good regio-, diastereo-, and enantioselectivity. This process represents the first highly enantioselective palladium-carbenoid-mediated reaction. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：13356 / 13360
页数：5
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