Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity

被引:42
|
作者
Mentese, Emre [1 ]
Bektas, Hakan [2 ]
Ulker, Serdar [3 ]
Bekircan, Olcay [4 ]
Kahveci, Bahittin [5 ]
机构
[1] Recep Tayyip Erdogan Univ, Fac Arts & Sci, Dept Chem, TR-53100 Rize, Turkey
[2] Giresun Univ, Fac Arts & Sci, Dept Chem, Giresun, Turkey
[3] Recep Tayyip Erdogan Univ, Fac Arts & Sci, Dept Biol, TR-53100 Rize, Turkey
[4] Karadeniz Tech Univ, Dept Chem, Fac Sci, TR-61080 Trabzon, Turkey
[5] Karadeniz Tech Univ, Fac Hlth Sci, Dept Nutr & Dietet, Trabzon, Turkey
关键词
Benzimidazole; iminoester hydrochloride; lipase inhibition; microwave; VITRO ANTIMICROBIAL ACTIVITY; SCREENING IN-VITRO; DESIGN; POTENT;
D O I
10.3109/14756366.2012.753880
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A practical protocol has been used for the synthesis of benzimidazoles. The reaction of iminoester hydrochlorides of phenylacetic with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole derivatives with good yields and in short reaction times. After the synthesis of benzimidazoles, we synthesized ester and hydrazide derivatives under microwave irradiation with good yields. All compounds were evaluated with regard to pancreatic lipase activity and 3b, 3c, 5a and 6a showed lipase inhibition at various concentrations.
引用
收藏
页码:64 / 68
页数:5
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