Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4 and relevance to substrate cooperativity

被引：0
|
作者：
Isin, EM [1 ]
Guengerich, FP [1 ]
机构：
[1] Vanderbilt Univ, Ctr Mol Toxicol, Nashville, TN 37232 USA
来源：
FASEB JOURNAL | 2006年 / 20卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：A458 / A458
页数：1
相关论文
共 50 条
  • [1] Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4
    Isin, EM
    Guengerich, FP
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (14) : 9127 - 9136
  • [2] P450 3A4: Development of reconstituted systems, cooperativity, and ligand binding
    Hosea, NA
    Shaw, P
    Kuwabara, T
    Guengerich, FP
    FASEB JOURNAL, 1997, 11 (09): : A810 - A810
  • [3] Peripheral Ligand Binding and Allostery in Cytochrome P450 3A4
    Davydov, Dmitri R.
    Rumfeldt, Jessica A. O.
    Sineva, Elena V.
    Davydova, Nadezhda Y.
    Halpert, James R.
    FASEB JOURNAL, 2012, 26
  • [4] Cooperativity in oxidations catalyzed by cytochrome P450 3A4
    Ueng, YF
    Kuwabara, T
    Chun, YJ
    Guengerich, FP
    BIOCHEMISTRY, 1997, 36 (02) : 370 - 381
  • [5] Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity
    Fernando, Harshica
    Rumfeldt, Jessica A. O.
    Davydova, Nadezhda Y.
    Halpert, James R.
    Davydov, Dmitri R.
    XENOBIOTICA, 2011, 41 (04) : 281 - 289
  • [6] Cooperativity in cytochrome P450 3A4 -: Linkages in substrate binding, spin state, uncoupling, and product formation
    Denisov, Ilia G.
    Baas, Bradley J.
    Grinkova, Yelena V.
    Sligar, Stephen G.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (10) : 7066 - 7076
  • [7] Elucidation of distinct ligand binding sites for cytochrome P450 3A4
    Hosea, NA
    Miller, GP
    Guengerich, FP
    BIOCHEMISTRY, 2000, 39 (20) : 5929 - 5939
  • [8] Kinetics of substrate binding to human Cytochrome P450 3A4: A study with Fluorol-7GA, a fluorescent allosteric ligand
    Rumfeldt, Jessica Anne Osborne
    Halpert, James R.
    Davydov, Dmitri R.
    FASEB JOURNAL, 2010, 24
  • [9] Multiple substrate binding by cytochrome P450 3A4:: Estimation of the number of bound substrate molecules
    Kapelyukh, Yury
    Paine, Mark J. I.
    Marechal, Jean-Didier
    Sutcliffe, Michael J.
    Wolf, C. Roland
    Roberts, Gordon C. K.
    DRUG METABOLISM AND DISPOSITION, 2008, 36 (10) : 2136 - 2144
  • [10] Structural basis for ligand promiscuity in cytochrome P450 3A4
    Ekroos, Marika
    Sjogren, Tove
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (37) : 13682 - 13687
12345