Callyaerin G, a new cytotoxic cyclic peptide from the marine sponge Callyspongia aerizusa

被引：35

作者：

Ibrahim, Sabrin R. M. ^{[2
]}

Edrada-Ebel, RuAngelie ^{[3
]}

Mohamed, Gamal A. ^{[4
]}

Youssef, Diaa T. A. ^{[5
]}

Wray, Victor ^{[6
]}

Proksch, Peter ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany

[2] Assiut Univ, Fac Pharm, Dept Pharmacognosy, Assiut 71526, Egypt

[3] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0NR, Lanark, Scotland

[4] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy, Assiut Branch, Assiut 71524, Egypt

[5] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt

[6] Helmholtz Ctr Infect Res, D-38124 Braunschweig, Germany

来源：

ARKIVOC | 2008年

关键词：

Callyspongia aerizusa; Callyaerin G; Marfey's analysis; cytotoxicity;

D O I：

10.3998/ark.5550190.0009.c18

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

From the ethyl acetate fraction of the Indonesian sponge Callyspongia aerizusa extract, a new cyclic peptide named callyaerin G was isolated. Its structure was elucidated by extensive 1D and 2D NMR (1H NMR, TOCSY and ROESY) studies and mass spectrometric data (ESI- and FAB-MS). The stereochemistry was determined by Marfey's analysis. Callyaerin G was found to exhibit cytotoxic activity when tested against different cancer cell lines.

引用

页码：164 / 171

页数：8

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