Cancer cell detection based on the interaction between an anticancer drug and cell membrane components

被引：63
|
作者：
Chandra, Pranjal
Noh, Hui-Bog
Shim, Yoon-Bo [1 ]
机构：
[1] Pusan Natl Univ, Dept Chem, Pusan 609735, South Korea
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 19期
关键词：
DAUNOMYCIN; AFFINITY; APTAMER;
D O I：
10.1039/c2cc38235k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Simple and general cancer cell detection methods are required in point-of-care diagnostics. Herein, the interaction between an anticancer drug, daunomycin, and cancer cell membrane components has been studied using an aptamer probe immobilized on a conducting polymer-gold nanoparticle composite film through electrochemical and fluorescence methods and applied to the quantitative detection of cancer cells. The developed method differentiates between cancerous and non-cancerous cells effectively.
引用
收藏
页码：1900 / 1902
页数：3
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