Evaluation of chromogranin A expression in serum and tissues of breast cancer patients

被引:17
|
作者
Giovanella, L
Marelli, M
Ceriani, L
Giardina, G
Garancini, S
Colombo, L
机构
[1] Univ Hosp Osped Circolo & Fdn Macchi, Dept Nucl Med, Lab Endocrinol & Oncol, I-21100 Varese, Italy
[2] Univ Hosp Osped Circolo & Fdn Macchi, Dept Surg, I-21100 Varese, Italy
[3] Univ Hosp Osped Circolo & Fdn Macchi, Dept Oncol, I-21100 Varese, Italy
[4] Univ Insubria, Varese, Italy
来源
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 2001年 / 16卷 / 04期
关键词
breast cancer; neuroendocrine; chromogranin A (CgA); CA; 15.3;
D O I
10.1177/172460080101600408
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Human chromogranin A (CgA) is a member of the granin family and is widely distributed in large dense core granules of endocrine and neuroendocrine cells. A variety of non-neuroendocrine carcinomas arising in various tissues show patterns of neuroendocrine differentiation. Expression of CgA has been documented in epithelial cells of normal mammary gland as well as in breast cancers, and elevation of serum CgA has been detected in patients with breast cancer. Our study was undertaken to evaluate the relationship between serum CgA levels and neuroendocrine features in breast cancer. In addition, we evaluated the expression of serum CgA in patients affected by breast cancer compared to controls and the relationship between serum CgA and tumor histology, extent of disease, lymph node status, tumor stage and serum CA 15.3 levels. We enrolled 266 patients with infiltrating ductal or lobular breast carcinoma and a group of 100 age-matched healthy women serving as controls. Serum CgA and CA 15.3 were assayed by specific immunoradiometric methods. The overall sensitivity of CgA and CA 15.3 was 0.06 and 0.34, respectively (chi(2) 19.1, p<0.0005). No relationship was found between serum levels of CgA and tumor histology, extent of disease, lymph node status or tumor stage while serum levels of CA 15.3 were strongly correlated with all these variables but tumor histology. No relationship was found between serum levels of CgA and CA 15.3. Immunostaining against CgA, CgB, NSE and synaptophysin was performed on primary tumor tissue of 14 serum CgA-positive and 24 serum CgA-negative patients and was negative in all cases. We also evaluated eight cases of pathologically-proven neuroendocrine breast cancer: only four and two of these showed positive CgA immunostaining and increased serum CgA concentration, respectively. In conclusion, serum CgA assay offers no additional information regarding the presence, the extent and the histology of breast cancer compared to the CA 15.3 assay. Moreover, serum CgA was not an accurate marker to identify or exclude the rare neuroendocrine differentiation of breast cancer. We therefore conclude that CgA is not useful as a serum marker in breast cancer.
引用
收藏
页码:268 / 272
页数:5
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