N4BP3 promotes breast cancer metastasis via NEDD4-mediated E-cadherin ubiquitination and degradation

被引：13
|
作者：
Luo, Meng [1 ,2 ]
Li, Jinfan [3 ]
Yang, Qi
Xu, Song [4 ]
Zhang, Kun [1 ]
Chen, Jing
Zhang, Suzhan [1 ]
Zheng, Shu [1 ]
Zhou, Jiaojiao [1 ,3 ,5 ,6 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 2, Dept Breast Surg & Oncol, Sch Med, Hangzhou 310009, Peoples R China
[2] Zhejiang Univ, Key Lab Canc Prevent & Intervent, China Natl Minist Educ, Sch Med, Hangzhou 310009, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 2, Dept Pathol, Sch Med, Hangzhou 310009, Peoples R China
[4] Zhejiang Univ, Lab Gastroenterol Dept, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Peoples R China
[5] Zhejiang Univ, Canc Ctr, Hangzhou 310009, Peoples R China
[6] Zhejiang Univ, Affiliated Hosp 2, Dept Breast Surg & Oncol, Coll Med, 88 Jie Fang Rd, Hangzhou 310009, Zhejiang, Peoples R China
来源：
CANCER LETTERS | 2022年 / 550卷
关键词：
N4BP3; NEDD4; E-cadherin; Breast cancer; Epithelial-mesenchymal transition; EPITHELIAL-MESENCHYMAL TRANSITION; CELL-ADHESION; PROTEIN; EXPRESSION; ENDOCYTOSIS; RECEPTOR; FAMILY; HAKAI;
D O I：
10.1016/j.canlet.2022.215926
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The molecular mechanisms driving metastatic progression in breast cancer patients remain poorly understood. Here, we identified N4BP3 as a new regulator in promoting breast cancer metastasis. N4BP3 is enriched in breast tumor tissue and negatively correlates with clinical outcomes in breast cancer patients. The results show that N4BP3 plays a crucial role in regulating breast cancer cell invasion in vitro, and N4BP3 depletion suppresses metastases formation in vivo. N4BP3 alters the expression of epithelial-mesenchymal transition markers and specifically targets E-cadherin in breast cancer cells. Intriguingly, we identified a novel E3 ligase NEDD4 for E-cadherin, and further revealed that N4BP3 promotes breast cancer metastasis via NEDD4-mediated E-cadherin ubiquitination and degradation. Together, this study uncovers an unprecedented role for N4BP3 in breast cancer metastasis and elucidates the underlying molecular mechanisms.
引用
收藏
页数：13
相关论文
共 50 条
  • [21] 14-3-3s-NEDD4L axis promotes ubiquitination and degradation of HIF-1a in colorectal cancer
    Liu, Sicheng
    Guo, Rui
    Xu, Hui
    Yang, Jinneng
    Luo, Haidan
    Yeung, Sai-Ching Jim
    Li, Kai
    Lee, Mong-Hong
    Yang, Runxiang
    CELL REPORTS, 2023, 42 (08):
  • [22] Loss of E-cadherin promotes prostate cancer metastasis via upregulation of metastasis-associated gene 1 expression
    Fan, Liangsheng
    Wang, Hongyan
    Xia, Xi
    Rao, Yumei
    Ma, Xiangyi
    Ma, Ding
    Wu, Peng
    Chen, Gang
    ONCOLOGY LETTERS, 2012, 4 (06) : 1225 - 1233
  • [23] Claudin-4/E-cadherin Index to Predict Prognosis in Breast Cancer
    Szasz, A.
    Gyorffy, B.
    Nemeth, Z.
    Krenacs, T.
    Baranyai, Z.
    Harsanyi, L.
    Dank, M.
    Madaras, L.
    Tokes, A. M.
    Kulka, J.
    EUROPEAN JOURNAL OF CANCER, 2011, 47 : S181 - S181
  • [24] The expressions of NEDD9 and E-cadherin correlate with metastasis and poor prognosis in triple-negative breast cancer patients
    Li, Peng
    Sun, Tingting
    Yuan, Qingzhong
    Pan, Guozheng
    Zhang, Jian
    Sun, Diwen
    ONCOTARGETS AND THERAPY, 2016, 9 : 5751 - 5759
  • [25] GATA4-activated lncRNA MALAT1 promotes osteogenic differentiation through inhibiting NEDD4-mediated RUNX1 degradation
    Xianzhe Huang
    Shuo Jie
    Wenzhao Li
    Chan Liu
    Cell Death Discovery, 9
  • [26] GATA4-activated lncRNA MALAT1 promotes osteogenic differentiation through inhibiting NEDD4-mediated RUNX1 degradation
    Huang, Xianzhe
    Jie, Shuo
    Li, Wenzhao
    Liu, Chan
    CELL DEATH DISCOVERY, 2023, 9 (01)
  • [27] Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer
    Zhou, Bo
    Xu, Hongbin
    Xia, Meng
    Sun, Chaoyang
    Li, Na
    Guo, Ensong
    Guo, Lili
    Shan, Wanying
    Lu, Hao
    Wu, Yifan
    Li, Yuan
    Yang, Degui
    Weng, Danhui
    Meng, Li
    Hu, Junbo
    Ma, Ding
    Chen, Gang
    Li, Kezhen
    FRONTIERS OF MEDICINE, 2017, 11 (02) : 214 - 222
  • [28] Loss of E-cadherin promotes ovarian cancer metastasis via α5-integrin, which is a therapeutic target
    Sawada, Kenjiro
    Mitra, Anirban K.
    Radjabi, A. Reza
    Bhaskar, Vinay
    Kistner, Emily O.
    Tretiakova, Maria
    Jagadeeswaran, Sujatha
    Montag, Anthony
    Becker, Amy
    Kenny, Hilary A.
    Peter, Marcus E.
    Ramakrishnan, Vanitha
    Yamada, S. Diane
    Lengyel, Ernst
    CANCER RESEARCH, 2008, 68 (07) : 2329 - 2339
  • [29] Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer
    Bo Zhou
    Hongbin Xu
    Meng Xia
    Chaoyang Sun
    Na Li
    Ensong Guo
    Lili Guo
    Wanying Shan
    Hao Lu
    Yifan Wu
    Yuan Li
    Degui Yang
    Danhui Weng
    Li Meng
    Junbo Hu
    Ding Ma
    Gang Chen
    Kezhen Li
    Frontiers of Medicine, 2017, 11 : 214 - 222
  • [30] Expression of S100A4, E-cadherin, α- and β-catenin in breast cancer biopsies
    Pedersen, KB
    Nesland, JM
    Fodstad, O
    Mælandsmo, GM
    BRITISH JOURNAL OF CANCER, 2002, 87 (11) : 1281 - 1286
12345