Synthesis of Some Novel Pyrazole-Substituted 9-Anilinoacridine Derivatives and Evaluation for their Antioxidant and Cytotoxic Activities

被引：24

作者：

Kalirajan, R. ^{[1
]}

Muralidharan, V. ^{[1
]}

Jubie, S. ^{[1
]}

Gowramma, B. ^{[1
]}

Gomathy, S. ^{[1
]}

Sankar, S. ^{[1
]}

Elango, K. ^{[1
]}

机构：

[1] JSS Univ, JSS Coll Pharm, Dept Pharmaceut Chem, Ootacamund 643001, Tamil Nadu, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2012年 / 49卷 / 04期

关键词：

N-MUSTARD RESIDUE; ANTITUMOR AGENTS; POTENT; ANILINO; BEARING;

D O I：

10.1002/jhet.848

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This article focuses on the synthesis of new series of pyrazole-substituted 9-anilinoacridine derivatives 5am and 6al. The compounds were confirmed by physical and analytical data. The synthesized compounds when screened for in vitro antioxidant activity showed promising activity for many compounds. The selected compounds were screened for cytotoxic activity showed promising inhibition of HEp-2 cell line for the compounds 6c, 6e, and 6f.

引用

页码：748 / 754

页数：7

共 50 条

[41] Synthesis of new pyrazole derivatives via multicomponent reaction and evaluation of their antimicrobial and antioxidant activities
Shivapura Viveka
Leelavathi Narayana Dinesha
Gundibasappa Karikannar Madhu
Monatshefte für Chemie - Chemical Monthly, 2015, 146 : 1547 - 1555
[42] Synthesis and Cytotoxicity Evaluation of Some Novel Tetrahydronaphthalene-Pyrazole Derivatives
El-Karim, Somaia S. Abd
Elsadek, M.
Baraka, M.
El-Zahar, M. I.
Rabou, M. S. Abd
EGYPTIAN JOURNAL OF CHEMISTRY, 2014, 57 (02): : 143 - 163
[43] Synthesis and evaluation of some novel substituted 1,3,4-oxadiazole and pyrazole derivatives for antitubercular activity
Pattan, Shashikant R.
Rabara, P. A.
Pattan, Jayashri S.
Bukitagar, A. A.
Wakale, V. S.
Musmade, D. S.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2009, 48 (10): : 1453 - 1456
[44] Synthesis of some heteroaryl pyrazole derivatives and their biological activities
陈寒松
李正名
ChineseJournalofChemistry, 2000, (04) : 596 - 602
[45] Synthesis of some heteroaryl pyrazole derivatives and their biological activities
Chen, HS
Li, ZM
CHINESE JOURNAL OF CHEMISTRY, 2000, 18 (04) : 596 - 602
[46] Design, synthesis and anticancer activities evaluation of novel pyrazole modified catalpol derivatives
Yuanfang Kong
Shuanglin Liu
Shaopei Wang
Bin Yang
Wei He
Hehe Li
Siqi Yang
Guoqing Wang
Chunhong Dong
Scientific Reports, 13
[47] Design, synthesis and anticancer activities evaluation of novel pyrazole modified catalpol derivatives
Kong, Yuanfang
Liu, Shuanglin
Wang, Shaopei
Yang, Bin
He, Wei
Li, Hehe
Yang, Siqi
Wang, Guoqing
Dong, Chunhong
SCIENTIFIC REPORTS, 2023, 13 (01)
[48] Synthesis, Antibacterial and Antioxidant Activities of Some New Nsubstituted Azachalcone, Schiff base and Pyrazole Derivatives
Caliskan, Nedime
Usta, Asu
Beris, Fatih Saban
Baltas, Nimet
Celik, Efsun
LETTERS IN ORGANIC CHEMISTRY, 2020, 17 (08) : 631 - 638
[49] A convenient synthesis of some novel pyrazole derivatives
Aly, ESA
El-Borai, MA
Barren, MA
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2004, 43 (06): : 1355 - 1359
[50] Synthesis and Antimicrobial Evaluation of Some Pyrazole Derivatives
Sharshira, Essam Mohamed
Hamada, Nagwa Mohamed Mahrous
MOLECULES, 2012, 17 (05): : 4962 - 4971

← 1 2 3 4 5 →