COMparison of Platelet reactivity following prAsugrel and ticagrelor loading dose in ST-Segment elevation myocardial infarctION patients: The COMPASSION study

被引：15

作者：

Laine, Marc ^{[1
]}

Gaubert, Melanie ^{[1
]}

Frere, Corinne ^{[2
]}

Peyrol, Michael ^{[1
]}

Thuny, Franck ^{[1
]}

Yvorra, Serge ^{[3
]}

Chelini, Virginie ^{[3
]}

Bultez, Bruno ^{[4
]}

Luigi, Stephane ^{[5
]}

Mokrani, Zair ^{[6
]}

Bessereau, Jacques ^{[7
]}

Toesca, Richard ^{[7
]}

Champenois, Anne ^{[7
]}

Dignat-George, Francoise ^{[2
]}

Paganelli, Franck ^{[1
]}

Bonello, Laurent ^{[1
]}

机构：

[1] Ctr Hosp Univ Nord, Serv Cardiol, Assistance Publ Hop Marseille, Marseille, France

[2] Hop Conception, Serv Pharm, Marseille, France

[3] Ctr Hosp Martigues, Serv Cardiol, Martigues, France

[4] Hop Sisteron, Serv Accueil Urgences, Sisteron, France

[5] Ctr Hosp Martigues, Serv Accueil Urgences, Martigues, France

[6] Ctr Hosp Salon de Provence, Serv Accueil Urgences, Salon De Provence, France

[7] CHU Marseille, Serv Aide Med Urgence, Marseille, France

来源：

PLATELETS | 2015年 / 26卷 / 06期

关键词：

Platelet reactivity; prasugrel; ST-segment elevation myocardial infarction; ticagrelor; VASP-index; CORONARY SYNDROME PATIENTS; CLOPIDOGREL; DEFINITION; CONSENSUS;

D O I：

10.3109/09537104.2014.959914

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Prasugrel and ticagrelor are potent P2Y(12)-ADP receptor antagonists which are superior to clopidogrel in acute coronary syndromes. To date no clinical trial directly compared these two drugs. Platelet reactivity correlates with ischemic and bleeding events in patients undergoing percutaneous coronary intervention. Recent pharmacological studies have observed a delayed onset of action of these two drugs in ST-segment elevation myocardial infarction (STEMI). We provide the first adequately powered pharmacological study comparing PR following ticagrelor and prasugrel loading dose (LD) in STEMI patients when the maximal biological effect is reached. In the present study, ticagrelor was associated with a lower rate of high on-treatment PR compared to prasugrel.

引用

页码：570 / 572

页数：3

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