Depot formulations to sustain periocular drug delivery to the posterior eye segment

被引：31
|
作者：
Agban, Yosra [1 ]
Thakur, Sachin S. [1 ]
Mugisho, Odunayo O. [1 ]
Rupenthal, Ilva D. [1 ]
机构：
[1] Univ Auckland, Fac Med & Hlth Sci, New Zealand Natl Eye Ctr, Dept Ophthalmol,Buchanan Ocular Therapeut Unit, Private Bag 92019, Auckland 1142, New Zealand
来源：
DRUG DISCOVERY TODAY | 2019年 / 24卷 / 08期
关键词：
BIODEGRADABLE INTRASCLERAL IMPLANT; INTRAVITREAL CONTROLLED-RELEASE; RETINAL-PIGMENT EPITHELIUM; TRANSSCLERAL DELIVERY; TRIAMCINOLONE ACETONIDE; HUMAN SCLERA; SUBCONJUNCTIVAL INJECTION; ANECORTAVE ACETATE; POLYMERIC DEVICE; NANO-PARTICLES;
D O I：
10.1016/j.drudis.2019.03.023
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The periocular space is a promising alternative route for the delivery of drugs to the posterior eye segment, especially when treating conditions in the outer ocular layers. In this review, we discuss the different periocular routes as well as the physiological barriers and elimination mechanisms limiting drug bioavailability at the back of the eye. We then highlight various types of depot formulations, including particulate delivery systems, semisolid formulations, and implants, used to increase the contact time with the ocular tissues. With the additional advantage of sustaining drug release, such depot formulations could enhance periocular drug delivery to the posterior eye segment.
引用
收藏
页码：1458 / 1469
页数：12
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