Bronchiolar Adenoma Transforming to Invasive Mucinous Adenocarcinoma: A Case Report

被引：13
|
作者：
Han, Xu [1 ,2 ]
Hao, Jialin [3 ]
Ding, Suling [4 ]
Wang, En-Hua [1 ,2 ]
Wang, Liang [1 ,2 ]
机构：
[1] China Med Univ, Affiliated Hosp 1, Dept Pathol, Shenyang, Peoples R China
[2] China Med Univ, Coll Basic Med Sci, Shenyang, Peoples R China
[3] China Med Univ, Key Lab Med Cell Biol, Minist Educ, Shenyang, Peoples R China
[4] Jinzhou Cent Hosp, Dept Pathol, Jinzhou, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2021年 / 14卷
关键词：
bronchiolar adenoma; invasive mucinous adenocarcinoma; KRAS; transformation;
D O I：
10.2147/OTT.S299864
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Bronchiolar adenoma (BA) is recognized as a neoplasm with benign clinical course. Histologically, BA is characterized by nodular proliferation of the bilayered bronchiolar-type epithelium, including multipartite epithelial cells and a continuous layer of basal cells. Recent reports have revealed the frequent presence of driver gene mutations in BA, suggesting its neoplastic nature. However, it is still debatable whether BA has malignant potential. Herein, we report the first case of BA harboring the same KRAS mutation with the adjacent invasive mucinous adenocarcinoma (IMA). Additionally, the loss of continuity of the basal cell layer in the junctional zone between BA and IMA indicated a malignant transformation from BA to IMA in this particular case.
引用
收藏
页码：2241 / 2246
页数：6
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