Detection of Potential Metastatic Prostate Cancer Circulating Biomarkers by Comparison of miRNA Profiles in DU145 Cells and Culture Medium

被引：16
|
作者：
Fomicheva, K. A. [1 ]
Osip'yants, A. I. [1 ]
Knyazev, E. N. [1 ]
Samatov, T. R. [2 ]
Shkurnikov, M. Yu. [1 ]
机构：
[1] Minist Hlth Russian Federat, Branch Natl Med Res Radiol Ctr, PA Hertsen Moscow Oncol Res Inst, Moscow, Russia
[2] BioClinicum Ctr, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 162卷 / 06期
关键词：
prostate cancer; miRNA; DU145;
D O I：
10.1007/s10517-017-3715-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the profile of miRNA secreted into culture medium by DU145 prostate cancer cells and identified a subset of miRNAs characterized by the absence of correlation of their content in the cell and medium, which is likely a result of specific secretion. Three of these miRNA, hsa-miR-4417, hsa-miR-3175, and hsa-miR-6782-5p, exhibit the highest expression and are candidate circulating biomarkers for metastatic activity of prostate cancer. Two of these miRNA are coded by introns of genes linked with genome stability maintenance and chromatin remodeling regulation.
引用
收藏
页码：792 / 796
页数：5
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