The Psychosis Spectrum in 22q11.2 Deletion Syndrome Is Comparable to That of Nondeleted Youths

被引：19

作者：

Tang, Sunny X. ^{[1
]}

Moore, Tyler M. ^{[1
]}

Calkins, Monica E. ^{[1
]}

Yi, James J. ^{[1
,3
]}

Savitt, Adam ^{[1
]}

Kohler, Christian G. ^{[1
]}

Souders, Margaret C. ^{[4
]}

Zackai, Elaine H. ^{[2
,4
]}

McDonald-McGinn, Donna M. ^{[2
,4
]}

Emanuel, Beverly S. ^{[2
,4
]}

Gur, Ruben C. ^{[1
]}

Gur, Raquel E. ^{[1
,3
]}

机构：

[1] Univ Penn, Dept Psychiat, Perelman Sch Med, 10th Floor Gates Bldg,3400 Spruce St, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat, Philadelphia, PA 19104 USA

[4] Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA

来源：

BIOLOGICAL PSYCHIATRY | 2017年 / 82卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Clinical high risk; DiGeorge syndrome; Prodromal; Psychosis; 22q11.2 Deletion syndrome; Schizophrenia; DEFICIT HYPERACTIVITY DISORDER; SCHOOL-AGE-CHILDREN; ULTRA-HIGH RISK; FOLLOW-UP; INTERRATER RELIABILITY; PSYCHIATRIC-DISORDERS; PRODROMAL SYNDROMES; SCHIZOPHRENIA; SYMPTOMS; ADOLESCENTS;

D O I：

10.1016/j.biopsych.2016.08.034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

BACKGROUND: Chromosome 22q11.2 deletion syndrome (22q11DS) is a promising model for studying psychosis risk. Direct comparisons of psychosis features between 22q11DS and nondeleted (ND) individuals are limited by inconsistency and small samples. In the largest study to date, we compare 22q11DS to ND in comorbidities, functioning, cognition, and psychosis features across the full range of overall severity. METHODS: ND youths (n = 150) ages 9 to 24 years were matched to 22q11DS individuals (n = 150) on age and sex, stratifying for presence of psychosis spectrum disorder. Individuals were evaluated for psychosis using the Structured Interview for Prodromal Syndromes, and for attention-deficit/hyperactivity, substance-related, and mood disorders. Differential item functioning analysis addressed whether 22q11DS differs from ND in the probability of clinically significant ratings while holding constant the overall level of psychosis. RESULTS: Onset of psychosis proneness was similar among 22q11DS (mean: 11.0 years) and ND (mean: 12.1 years) individuals. Accounting for higher overall psychosis symptoms, 22q11DS participants were still more likely to manifest impaired stress tolerance, avolition, and ideational richness; ND individuals were more likely to exhibit unusual thoughts, persecutory ideas, and bizarre thinking. Cognition was impaired in 22q11DS, but it did not correlate with symptoms except ideational richness. Comorbid anxiety disorders were more likely in psychosis spectrum 22q11DS; substance-related disorders were more likely in ND. Global assessment of function was similar in 22q11DS and ND individuals, except among those with low total Structured Interview for Prodromal Syndromes scores. CONCLUSIONS: Individuals with 22q11DS share overarching similarities with ND individuals in psychosis symptoms and age of onset for psychosis proneness; this continues to support the 22q11DS model as a valuable window into mechanisms contributing to psychosis.

引用

页码：17 / 25

页数：9

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