Plasmid-Encoded Transferable mecB-Mediated Methicillin Resistance in Staphylococcus aureus

被引：146

作者：

Becker, Karsten ^{[1
]}

van Alen, Sarah ^{[2
]}

Idelevich, Evgeny A. ^{[2
]}

Schleimer, Nina ^{[2
]}

Seggewiss, Jochen ^{[2
]}

Mellmann, Alexander ^{[2
]}

Kaspar, Ursula ^{[2
]}

Peters, Georg ^{[2
,3
]}

机构：

[1] Univ Hosp Munster, Inst Med Microbiol, Med Microbiol, Munster, Germany

[2] Univ Hosp Munster, Munster, Germany

[3] Cells Mot, Munster, Germany

来源：

EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 02期

关键词：

CASSETTE CHROMOSOME MEC; IN-VITRO ACTIVITY; COAGULASE-NEGATIVE STAPHYLOCOCCI; GERMAN GENERAL-POPULATION; CLONAL COMPLEX 398; MACROCOCCUS-CASEOLYTICUS; ANTIMICROBIAL RESISTANCE; BACTERIOPHAGE ENDOLYSIN; MRSA; CEFTAROLINE;

D O I：

10.3201/eid2402.171074

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During cefoxitin-based nasal screening, phenotypically categorized methicillin-resistant Staphylococcus aureus (MRSA) was isolated and tested negative for the presence of the mecA and mecC genes as well as for the SCCmec-orfX junction region. The isolate was found to carry a mecB gene previously described for Macrococcus caseolyticus but not for staphylococcal species. The gene is flanked by beta-lactam regulatory genes similar to mecR, mecI, and blaZ and is part of an 84.6-kb multidrug-resistance plasmid that harbors genes encoding additional resistances to aminoglycosides (aacA-aphD, aphA, and aadK) as well as macrolides (ermB) and tetracyclines (tetS). This further plasmid-borne beta-lactam resistance mechanism harbors the putative risk of acceleration or reacceleration of MRSA spread, resulting in broad ineffectiveness of beta-lactams as a main therapeutic application against staphylococcal infections.

引用

页码：242 / 248

页数：7

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