Plasmid-Encoded Transferable mecB-Mediated Methicillin Resistance in Staphylococcus aureus

被引：146

作者：

Becker, Karsten ^{[1
]}

van Alen, Sarah ^{[2
]}

Idelevich, Evgeny A. ^{[2
]}

Schleimer, Nina ^{[2
]}

Seggewiss, Jochen ^{[2
]}

Mellmann, Alexander ^{[2
]}

Kaspar, Ursula ^{[2
]}

Peters, Georg ^{[2
,3
]}

机构：

[1] Univ Hosp Munster, Inst Med Microbiol, Med Microbiol, Munster, Germany

[2] Univ Hosp Munster, Munster, Germany

[3] Cells Mot, Munster, Germany

来源：

EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 02期

关键词：

CASSETTE CHROMOSOME MEC; IN-VITRO ACTIVITY; COAGULASE-NEGATIVE STAPHYLOCOCCI; GERMAN GENERAL-POPULATION; CLONAL COMPLEX 398; MACROCOCCUS-CASEOLYTICUS; ANTIMICROBIAL RESISTANCE; BACTERIOPHAGE ENDOLYSIN; MRSA; CEFTAROLINE;

D O I：

10.3201/eid2402.171074

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During cefoxitin-based nasal screening, phenotypically categorized methicillin-resistant Staphylococcus aureus (MRSA) was isolated and tested negative for the presence of the mecA and mecC genes as well as for the SCCmec-orfX junction region. The isolate was found to carry a mecB gene previously described for Macrococcus caseolyticus but not for staphylococcal species. The gene is flanked by beta-lactam regulatory genes similar to mecR, mecI, and blaZ and is part of an 84.6-kb multidrug-resistance plasmid that harbors genes encoding additional resistances to aminoglycosides (aacA-aphD, aphA, and aadK) as well as macrolides (ermB) and tetracyclines (tetS). This further plasmid-borne beta-lactam resistance mechanism harbors the putative risk of acceleration or reacceleration of MRSA spread, resulting in broad ineffectiveness of beta-lactams as a main therapeutic application against staphylococcal infections.

引用

页码：242 / 248

页数：7

共 50 条

[1] PLASMID-ENCODED RESISTANCE TO ACRIFLAVINE AND QUATERNARY AMMONIUM-COMPOUNDS IN METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS
GILLESPIE, MT
MAY, JW
SKURRAY, RA
[J]. FEMS MICROBIOLOGY LETTERS, 1986, 34 (01) : 47 - 51
[2] Macrococcus canis contains recombinogenic methicillin resistance elements and the mecB plasmid found in Staphylococcus aureus
Chanchaithong, Pattrarat
Perreten, Vincent
Schwendener, Sybille
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2019, 74 (09) : 2531 - 2536
[3] The Staphylococcus aureus CsoR regulates both chromosomal and plasmid-encoded copper resistance mechanisms
Baker, Jonathan
Sengupta, Mrittika
Jayaswal, Radheshyan K.
Morrissey, Julie A.
[J]. ENVIRONMENTAL MICROBIOLOGY, 2011, 13 (09) : 2495 - 2507
[4] PLASMID-ENCODED RESISTANCE TO TETRACYCLINE IN STAPHYLOCOCCUS-HAEMOLYTICUS
SCHWARZ, S
[J]. LETTERS IN APPLIED MICROBIOLOGY, 1992, 15 (04) : 142 - 145
[5] PLASMID-ENCODED RESISTANCE TO MACROLIDES AND LINCOSAMIDES IN STAPHYLOCOCCUS-HYICUS
SCHWARZ, S
WEGENER, H
BLOBEL, H
[J]. JOURNAL OF APPLIED BACTERIOLOGY, 1990, 69 (06): : 845 - 849
[6] PLASMID-ENCODED FOSFOMYCIN RESISTANCE
SUAREZ, JE
MENDOZA, MC
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (05) : 791 - 795
[7] EPIDERMOLYTIC TOXIN SEROTYPE-B OF STAPHYLOCOCCUS-AUREUS IS PLASMID-ENCODED
OTOOLE, PW
FOSTER, TJ
[J]. FEMS MICROBIOLOGY LETTERS, 1986, 36 (2-3) : 311 - 314
[8] PLASMID-ENCODED RESISTANCE TO ARSENIC AND ANTIMONY
KAUR, P
ROSEN, BP
[J]. PLASMID, 1992, 27 (01) : 29 - 40
[9] In vitro plasmid-encoded resistance to quinolones
GomezGomez, JM
Blazquez, J
DelosMonteros, LEE
Baquero, MR
Baquero, F
Martinez, JL
[J]. FEMS MICROBIOLOGY LETTERS, 1997, 154 (02) : 271 - 276
[10] PLASMID-ENCODED METAL RESISTANCE IN BACTERIA
RANI, DBR
MAHADEVAN, A
[J]. JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH, 1989, 48 (07): : 338 - 345

← 1 2 3 4 5 →