Solid-phase synthesis of CD40L mimetics

被引：10
|
作者：
Bianco, A [1 ]
Fournel, S [1 ]
Wieckowski, S [1 ]
Hoebeke, J [1 ]
Guichard, G [1 ]
机构：
[1] CNRS, Inst Biol Mol & Cellulaire, UPR 9021, F-67084 Strasbourg, France
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 08期
关键词：
D O I：
10.1039/b601528j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The C-3-symmetric molecule 1 has been previously shown to mimic CD40 ligand (CD40L) homotrimers and to display effector functions. This molecule consists of a cyclic hexapeptide core containing the repetition of the D-Ala-L-Lys motif. The side chains of the lysine residues have been modified by appending the CD40L-derived sequence (143)Lys-Gly-Tyr-Tyr(146) via a 6-aminohexanoic acid residue as a spacer. The present report describes a general solid-phase synthesis approach to 1 and related trimeric architectures. In addition, their CD40 binding properties as well as their effector functions have been evaluated.
引用
收藏
页码：1461 / 1463
页数：3
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