A bromine analogue of picoplatin: a new substance from the group of platinum-based chemotherapeutics

被引：3
|
作者：
Pazout, Richard [1 ]
Maixner, Jaroslav [1 ]
Hrda, Michaela [2 ]
Louzilova, Tereza [2 ]
Kacer, Petr [2 ]
机构：
[1] Inst Chem Technol, Cent Labs, CR-16628 Prague, Czech Republic
[2] Inst Chem Technol, Dept Organ Technol, CR-16628 Prague, Czech Republic
来源：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY | 2013年 / 69卷
关键词：
Molecules - Bromine - Chains - Platinum compounds;
D O I：
10.1107/S0108270113004708
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new substance, cis-amminedibromido(2-methylpyridine-N)platinum(II), cis-[PtBr2(C6H7N)(NH3)], which is a potential platinum-based antineoplastic agent for the treatment of patients with solid tumors, has been synthesized and structurally characterized. There is one molecule in the asymmetric unit and molecules are linked via two symmetry-independent NH...Br hydrogen bonds into zigzag chains running parallel to the c axis. CH...Br hydrogen bonds crosslink these chains to give a layer parallel to (010). NH...Br hydrogen bonds and stacking interactions between pairs of pyridine rings stack the layers along b.
引用
收藏
页码：337 / +
页数：7
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