Central Nervous System Involvement of Rhabdomyosarcoma: A Single Institution Experience

被引：3
|
作者：
Moreira, Daniel C.
Macy, Margaret E.
Cost, Carrye R.
Greffe, Brian S.
Garrington, Timothy P. [1 ]
机构：
[1] Childrens Hosp Colorado, 13123 E 16th Ave,B115, Aurora, CO 80045 USA
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2019年 / 41卷 / 02期
关键词：
rhabdomyosarcoma; CNS involvement; CNS metastasis; leptomeningeal enhancement; BRAIN METASTASIS; SARCOMA; PHARMACOKINETICS; EXPOSURE; CHILDREN;
D O I：
10.1097/MPH.0000000000001166
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The incidence of central nervous system (CNS) involvement in patients with rhabdomyosarcoma (RMS) is low, and the outcome is dismal. We present a single institution analysis of CNS involvement of pediatric RMS. In 59 patients, the prevalence of CNS involvement was 11.9% (7 patients), higher than prior reports. Of the 6 deaths from disease, all had rapid progression, with a median survival of 14 days. The higher incidence could be secondary to treatment modifications or more sensitive detection. These findings are useful for decisions at the time of CNS involvement and could lead to modifications for future RMS clinical trials.
引用
收藏
页码：152 / 154
页数：3
相关论文
共 50 条
  • [21] The burden of radiation-induced central nervous system tumors: A single institution's experience
    Kleinschmidt-DeMasters, B. K.
    Kang, Jennifer S.
    Lillehei, Kevin O.
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2006, 65 (03): : 204 - 216
  • [22] CENTRAL NERVOUS SYSTEM RECURRENCE IN AGGRESSIVE B-CELL LYMPHOMA: A SINGLE INSTITUTION EXPERIENCE
    Chekan, A.
    Kichigina, M.
    Tumyan, G.
    Kovrigina, A.
    Tupitsin, N.
    Trofimova, O.
    Bykov, D.
    Poddubnaya, I.
    Osmanov, D.
    [J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 : 635 - 636
  • [23] Patterns, treatments, and outcomes of pediatric central nervous system tumors in Sudan: a single institution experience
    Elhassan, M. Mohammed Ali
    Mohamedani, A. Abdalla
    Osman, H. Hussein Mohammed
    Yousif, N. Osman
    Elhaj, N. Mohamed
    Qaddoumi, I.
    [J]. CHILDS NERVOUS SYSTEM, 2019, 35 (03) : 437 - 444
  • [24] Patterns, treatments, and outcomes of pediatric central nervous system tumors in Sudan: a single institution experience
    M. Mohammed Ali Elhassan
    A. Abdalla Mohamedani
    H. Hussein Mohammed Osman
    N. Osman Yousif
    N. Mohamed Elhaj
    I. Qaddoumi
    [J]. Child's Nervous System, 2019, 35 : 437 - 444
  • [25] Central Nervous System Involvement in Children With Rhabdomyosarcoma: Molecular Characterization of Cerebrospinal Fluid
    Zin, Angelica
    Poli, Elena
    Bisogno, Gianni
    Brunello, Antonella
    Garaventa, Alberto
    Burnelli, Roberta
    Bertolini, Patrizia
    Miglionico, Lucia
    Cerri, Carla
    De Sio, Luigi
    Nardi, Margherita
    Provenzi, Massimo
    Rosolen, Angelo
    [J]. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2014, 36 (04) : 322 - 323
  • [26] Safety and Efficacy of Blinatumomab in Patients with Central Nervous System (CNS) Disease: A Single Institution Experience
    Alfayez, Mansour
    Kantarjian, Hagop M.
    Short, Nicholas J.
    Assi, Rita
    Khouri, Maria
    Ravandi, Farhad
    Paul, Shilpa
    Rausch, Caitlin R.
    Nasnas, Patrice
    Borthakur, Gautam
    DiNardo, Courtney D.
    Kadia, Tapan M.
    Daver, Naval G.
    Garcia-Manero, Guillermo
    Naqvi, Kiran
    Bose, Prithviraj
    O'Brien, Susan M.
    Cortes, Jorge E.
    Jabbour, Elias J.
    [J]. BLOOD, 2018, 132
  • [27] Tumors of the Central Nervous System in the First Year of Life. One Single Institution Experience
    Garcia-Ariza, M.
    Echebarria Barona, A.
    Lopez-Almaraz, R.
    Adan Pedroso, R.
    Bilbao Salcines, N.
    Ricondo De Diego, A.
    Ojinaga Nino, I.
    Galbarriatu Gutierrez, L.
    de Gopegui Ruiz, E. Ruiz
    Aurtenetxe Saez, O.
    Martin Guerrero, I.
    Zaldumbide Duenas, L.
    Navajas, A.
    Astigarraga Aguirre, I.
    [J]. PEDIATRIC BLOOD & CANCER, 2017, 64 : S462 - S462
  • [28] RHABDOMYOSARCOMA EXPERIENCE: A SINGLE INSTITUTION'S RESULTS
    Mutafoglu, K.
    Ince, D.
    Kizmazoglu, D.
    Erdem, M.
    Ataseven, E.
    Yenigurbuz, F.
    Ozer, E.
    Olguner, M.
    Demiral, A.
    Guleryuz, H.
    Olgun, N.
    [J]. PEDIATRIC BLOOD & CANCER, 2015, 62 : S371 - S371
  • [29] Central nervous system relapse of rhabdomyosarcoma
    De, Brian
    Kinnaman, Michael D.
    Wexler, Leonard H.
    Kramer, Kim
    Wolden, Suzanne L.
    [J]. PEDIATRIC BLOOD & CANCER, 2018, 65 (01)
  • [30] Central nervous system relapse of rhabdomyosarcoma
    De, B.
    Kinnaman, M. D.
    Wexler, L. H.
    Kramer, K.
    Wolden, S. L.
    [J]. PEDIATRIC BLOOD & CANCER, 2017, 64 (11)
12345