Development of a dual inhibitor of pan-RAF and VEGFR2 for the treatment of metastatic colorectal cancer with mutant K-RAS

被引:0
|
作者
Hong, Sungpyo
Choi, Young-Il
Choi, Jihye
Kim, Wonyoung
Kwon, Ho-Seok
Park, Yong Bin
Ki, Min-Hyo
Shin, Hee Jong
Lee, Michael
Ahn, Soon Kil
机构
关键词
D O I
10.1158/1538-7445.AM2016-3782
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3782
引用
收藏
页数:4
相关论文
共 50 条
  • [11] Antitumor activity of KIN-2787, a next-generation pan-RAF inhibitor, in preclinical models of human RAF/RAS mutant melanoma
    Miller, Nichol L. G.
    Wang, Tim S.
    Severson, Paul
    Jiang, Ping
    Perez, Michelle
    Timple, Noel
    Kanouni, Toufike
    Franovic, Aleksandra
    Martin, Eric S.
    Murphy, Eric
    CANCER RESEARCH, 2022, 82 (12)
  • [12] Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor
    Huestis, Malcolm P.
    Dela Cruz, Darlene
    DiPasquale, Antonio G.
    Durk, Matthew R.
    Eigenbrot, Charles
    Gibbons, Paul
    Gobbi, Alberto
    Hunsaker, Thomas L.
    La, Hank
    Leung, Dennis H.
    Liu, Wendy
    Malek, Shiva
    Merchant, Mark
    Moffat, John G.
    Muli, Christine S.
    Orr, Christine J.
    Parr, Brendan T.
    Shanahan, Frances
    Sneeringer, Christopher J.
    Wang, Weiru
    Yen, Ivana
    Yin, Jianping
    Siu, Michael
    Rudolph, Joachim
    ACS MEDICINAL CHEMISTRY LETTERS, 2021, 12 (05): : 791 - 797
  • [13] JZP815, a potent and selective pan-RAF inhibitor, demonstrates efficacy in RAF and RAS mutant tumor pre-clinical models
    Hauptschein, Robert
    Woodcock, Simon
    Belfield, Andrew
    Mason, Helen
    Keppel, Dorottya
    Markova, Svetlana
    Kim, Kyuri
    Roller, Shane
    Phillips, Caroline
    Jones, Clifford D.
    Humphreys, Robin C.
    CANCER RESEARCH, 2022, 82 (12)
  • [14] A Phase I Study of LY3009120, a Pan-RAF Inhibitor, in Patients with Advanced or Metastatic Cancer
    Sullivan, Ryan J.
    Hollebecque, Antoine
    Flaherty, Keith T.
    Shapiro, Geoffrey I.
    Ahnert, Jordi Rodon
    Millward, Michael J.
    Zhang, Wei
    Gao, Ling
    Sykes, Amanda
    Willard, Melinda D.
    Yu, Danni
    Schade, Andrew E.
    Crowe, KrisAnne
    Flynn, Daniel L.
    Kaufman, Michael D.
    Henry, James R.
    Peng, Sheng-Bin
    Benhadji, Karim A.
    Conti, Ilaria
    Gordon, Michael S.
    Tiu, Ramon V.
    Hong, David S.
    MOLECULAR CANCER THERAPEUTICS, 2020, 19 (02) : 460 - 467
  • [15] SIMVASTATIN CAUSES TRANSLOCATION OF MUTANT K-RAS IN COLORECTAL CANCER CELLS
    Krens, L. L.
    Pullen, C. M. C.
    Baak-Pablo, R. F.
    Guchelaar, H. J.
    van der Straaten, R. J. H. M.
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 78 (04) : 768 - 769
  • [16] K-Ras mutation status as a predictive biomarker in metastatic colorectal cancer
    Ramos, Francisco Javier
    Tabernero, Josep
    BIOMARKERS IN MEDICINE, 2008, 2 (02) : 97 - 99
  • [17] K-ras mutatation is a marker of accelerated metastatic progression in colorectal cancer
    Nash, GM
    Gimbel, M
    Nathanson, D
    Zeng, ZS
    Gerald, W
    Kemeny, N
    Fong, YM
    Paty, P
    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2003, 197 (03) : S10 - S10
  • [18] Metastatic colorectal cancer first-line treatment with bevacizumab: the impact of K-ras mutation
    Rossi, Luigi
    Veltri, Enzo
    Zullo, Angelo
    Zoratto, Federica
    Colonna, Maria
    Longo, Flavia
    Mottolese, Marcella
    Giannarelli, Diana
    Ruco, Luigi
    Marchetti, Paolo
    Romiti, Adriana
    Barucca, Viola
    Giannini, Giuseppe
    Bianchi, Loredana
    Tomao, Silverio
    ONCOTARGETS AND THERAPY, 2013, 6 : 1761 - 1769
  • [19] Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer
    Kopreski, MS
    Benko, FA
    Kwee, C
    Leitzel, KE
    Eskander, E
    Lipton, A
    Gocke, CD
    BRITISH JOURNAL OF CANCER, 1997, 76 (10) : 1293 - 1299
  • [20] Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer
    MS Kopreski
    FA Benko
    C Kwee
    KE Leitzel
    E Eskander
    A Lipton
    CD Gocke
    British Journal of Cancer, 1997, 76 : 1293 - 1299