Biomimetic detection of aminoglycosidic antibiotics using polydiacetylene-phospholipids supramolecules

被引：51
|
作者：
Kang, Do Hyun [2 ]
Jung, Ho-Sup
Ahn, Namyoung
Lee, Jiseok [1 ]
Seo, Sungbaek [1 ]
Suh, Kahp-Yang [2 ,3 ]
Kim, Jinsang [1 ]
Kim, Keesung [3 ]
机构：
[1] Univ Michigan, Ann Arbor, MI 48109 USA
[2] Seoul Natl Univ, Sch Mech & Aerosp Engn, Div WCU Multiscale Mech Design, Seoul 151742, South Korea
[3] Seoul Natl Univ, Inst Adv Machinery & Design, Seoul 151742, South Korea
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 43期
基金：
美国国家科学基金会; 新加坡国家研究基金会;
关键词：
PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; COLORIMETRIC DETECTION; VESICLES; NEOMYCIN; INHIBITION; COLOR; ASSAY; MILK;
D O I：
10.1039/c2cc31466e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We rationally designed highly sensitive and selective polydiacetylene (PDA)-phospholipids liposomes for the facile detection of aminoglycosidic antibiotics. The detecting mechanism mimics the cellular membrane interactions between neomycin and phosphatidylinositol-4,5-bisphosphate (PIP2) phospholipids. The developed PDA-PIP2 sensory system showed a detection limit of 61 ppb for neomycin and was very specific to aminoglycosidic antibodies only.
引用
收藏
页码：5313 / 5315
页数：3
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