Next-Generation Sequencing: Targeting Targeted Therapies

被引:9
|
作者
McCutcheon, Justine N. [1 ]
Giaccone, Giuseppe [1 ]
机构
[1] Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA
关键词
CELL LUNG-CANCER; EGFR; RESISTANCE; GEFITINIB; MUTATION;
D O I
10.1158/1078-0432.CCR-15-0407
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Next-generation sequencing (NGS) has given new perspective in oncology. With the ongoing development of targeted therapies, NGS is evolving molecular diagnostics by providing comprehensive interrogation of clinically actionable genomic aberrations in tumors. Having this assay as the primary testing method produces clinically beneficial results. (C)2015 AACR.
引用
收藏
页码:3584 / 3585
页数:2
相关论文
共 50 条
  • [21] Next-Generation Sequencing: Next-Generation Quality in Pediatrics
    Wortmann, Saskia B.
    Spenger, Johannes
    Preisel, Martin
    Koch, Johannes
    Rauscher, Christian
    Bader, Ingrid
    Mayr, Johannes A.
    Sperl, Wolfgang
    [J]. PADIATRIE UND PADOLOGIE, 2018, 53 (06): : 278 - 283
  • [22] Next-Generation Sequencing Demands Next-Generation Phenotyping
    Hennekam, Raoul C. M.
    Biesecker, Leslie G.
    [J]. HUMAN MUTATION, 2012, 33 (05) : 884 - 886
  • [23] Application of metagenomic next-generation sequencing and targeted metagenomic next-generation sequencing in diagnosing pulmonary infections in immunocompetent and immunocompromised patients
    Liu, Yong
    Wu, Wencai
    Xiao, Yunping
    Zou, Hongyan
    Hao, Sijia
    Jiang, Yanfang
    [J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2024, 14
  • [24] Comprehensive Next-Generation Sequencing Guided Targeted Therapies Improve Clinical Outcomes of Lung Cancer Patients
    Wang, Z.
    Zhu, D.
    Lu, B.
    Liu, G.
    Xu, T.
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2018, 13 (10) : S704 - S704
  • [25] Role of next-generation sequencing in vitreoretinal lymphomas (VRL): A new approach to targeted therapies and disease monitoring
    Greenwood, Michael
    Alrabeh, Reem
    Ewton, April
    Cheves-Barrios, Patricia
    Thomas, Jessica
    Olsen, Randall
    [J]. LABORATORY INVESTIGATION, 2018, 98 : 658 - 658
  • [26] Role of next-generation sequencing in vitreoretinal lymphomas (VRL): A new approach to targeted therapies and disease monitoring
    Greenwood, Michael
    Alrabeh, Reem
    Ewton, April
    Cheves-Barrios, Patricia
    Thomas, Jessica
    Olsen, Randall
    [J]. MODERN PATHOLOGY, 2018, 31 : 658 - 658
  • [27] Next-Generation Sequencing Reveals Pathway Activations and New Routes to Targeted Therapies in Cutaneous Metastatic Melanoma
    Carlson, J. Andrew
    Caldeira Xavier, Jose Candido, Jr.
    Tarasen, Ashley
    Sheehan, Christine E.
    Otto, Geoff
    Miller, Vincent A.
    Stephens, Philip J.
    Elvin, Julia A.
    Vergilio, Jo-Anne
    Suh, James
    Gay, Laurie M.
    Ross, Jeffrey S.
    [J]. AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2017, 39 (01) : 1 - 13
  • [28] Next-Generation Sequencing
    Le Gallo, Matthieu
    Lozy, Fred
    Bell, Daphne W.
    [J]. MOLECULAR GENETICS OF ENDOMETRIAL CARCINOMA, 2017, 943 : 119 - 148
  • [29] Next-generation sequencing
    Haferlach, T.
    [J]. ONCOLOGY RESEARCH AND TREATMENT, 2016, 39 : 40 - 41
  • [30] Next-Generation Sequencing
    Xiong, Momiao
    Zhao, Zhongming
    Arnold, Jonathan
    Yu, Fuli
    [J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010,