The MHC2TA 1614 C<G gene polymorphism is associated with risk of developing acute coronary syndrome

Background: Inflammation plays an essential role in the development and progression of atherosclerotic lesions. The major histocompatibility complex class II trans-activator (MHC2TA) is considered an important molecule in the inflammatory process regulation. The aim of the present study was to evaluate the role of MHC2TA gene polymorphisms as susceptibility markers for acute coronary syndrome (ACS). Methods: Three polymorphisms (-168 A>G, 1614 C>G, and 2536 G>A) of the MHC2TA gene were analyzed by 5' exonuclease TagMan genotyping assays in a group of 297 patients with ACS and 283 healthy controls. Haplotypes were constructed after linkage disequilibrium analysis. Results: The 1614 C allele and CC genotype were associated with risk of developing ACS (PC=0.014, OR=1.37 and PC=0.006, OR=1.90, respectively). Based on Hosmer-Lemeshow Goodness of Fit test, the recessive model was selected to estimate risk between ACS patients and controls adjusted by cardiovascular risk factors using a multiple logistic analysis. In this case, the OR adjusted was 1.78 for the 1614 CC genotype (P=0.023). The analysis of linkage disequilibrium showed one risk haplotype (ACG) and one protective haplotype (AGG) for developing ACS (P=0.02, OR=1.5 and P=0.04, OR=0.72, respectively). Conclusion: The results suggest that MHC2TA 1614 gene polymorphism could be involved in the risk of developing ACS. (C) 2013 Elsevier Ltd. All rights reserved.