Hyperexcitability of the hippocampal neurons in the synaptic vesicle protein SV2A mutant rats

被引：0
|
作者：
Tokudome, Kentaro [1 ]
Okumura, Takahiro [1 ]
Shimizu, Saki [1 ]
Kunisawa, Naofumi [1 ]
Tomita, Chisato [1 ]
Kitaya, Ryosuke [1 ]
Mashimo, Tomoji [2 ]
Serikawa, Tadao [2 ]
Sasa, Masashi [3 ]
Ohno, Yukihiro [1 ]
机构：
[1] Osaka Univ Pharm Sci, Pharmacol Lab, Takatsuki, Osaka 5691094, Japan
[2] Kyoto Univ, Sch Med, Inst Lab Anim, Sakyo Ku, Kyoto 6068501, Japan
[3] Nagisa Clin, Hirakata, Osaka 5731183, Japan
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2013年 / 121卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：155P / 155P
页数：1
相关论文
共 50 条
  • [41] Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
    Ellis Chika Onwordi
    Els F. Halff
    Thomas Whitehurst
    Ayla Mansur
    Marie-Caroline Cotel
    Lisa Wells
    Hannah Creeney
    David Bonsall
    Maria Rogdaki
    Ekaterina Shatalina
    Tiago Reis Marques
    Eugenii A. Rabiner
    Roger N. Gunn
    Sridhar Natesan
    Anthony C. Vernon
    Oliver D. Howes
    Nature Communications, 11
  • [42] Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography ( PET) Ligands
    Mercier, Joel
    Archen, Laurence
    Bollu, Veronique
    Carre, Stephane
    Evrard, Yves
    Jnoff, Eric
    Kenda, Benoit
    Lallemand, Benedicte
    Michel, Philippe
    Montel, Florian
    Moureau, Florence
    Price, Nathalie
    Quesnel, Yannick
    Sauvage, Xavier
    Valade, Anne
    Provins, Laurent
    CHEMMEDCHEM, 2014, 9 (04) : 693 - 698
  • [43] Imaging the Effect of Ketamine on Synaptic (SV2A) Density
    Holmes, Sophie
    Finnema, Sjoerd
    Naganawa, Mika
    DellaGioia, Nicole
    Holden, Daniel
    Fowles, Krista
    Ropchan, Jim
    Emory, Paul
    Ye, Yunpeng
    Nabulsi, Nabeel
    Matuskey, David
    Angarita, Gustavo
    Duman, Ronald
    Sanacora, Gerard
    Krystal, John
    Carson, Richard
    Esterlis, Irina
    BIOLOGICAL PSYCHIATRY, 2021, 89 (09) : S35 - S35
  • [44] Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons
    Singec, I
    Knoth, R
    Ditter, M
    Hagemeyer, CE
    Rosenbrock, H
    Frotscher, M
    Volk, B
    JOURNAL OF COMPARATIVE NEUROLOGY, 2002, 452 (02) : 139 - 153
  • [45] Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
    Onwordi, Ellis Chika
    Halff, Els F.
    Whitehurst, Thomas
    Mansur, Ayla
    Cotel, Marie-Caroline
    Wells, Lisa
    Creeney, Hannah
    Bonsall, David
    Rogdaki, Maria
    Shatalina, Ekaterina
    Marques, Tiago Reis
    Rabiner, Eugenii A.
    Gunn, Roger N.
    Natesan, Sridhar
    Vernon, Anthony C.
    Howes, Oliver D.
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [46] SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling
    Small, Christopher
    Harper, Callista
    Jiang, Anmin
    Kontaxi, Christiana
    Pronot, Marie
    Yak, Nyakuoy
    Malapaka, Anusha
    Davenport, Elizabeth C.
    Wallis, Tristan P.
    Gormal, Rachel S.
    Joensuu, Merja
    Martinez-Marmol, Ramon
    Cousin, Michael A.
    Meunier, Frederic A.
    JOURNAL OF NEUROCHEMISTRY, 2024, 168 (09) : 3188 - 3208
  • [47] SV2A PET shows hippocampal synaptic loss in cognitively unimpaired APOE ε4/ε4 homozygotes
    Snellman, Anniina
    Tuisku, Jouni
    Koivumaki, Mikko
    Wahlroos, Saara
    Aarnio, Richard
    Rajander, Johan
    Karrasch, Mira
    Ekblad, Laura L.
    Rinne, Juha O.
    ALZHEIMERS & DEMENTIA, 2024,
  • [48] Rapid kindling and hippocampal hyperexcitability differentiate heterozygous SV2A KO mice from wild type controls: Further evidence for SV2A being the principal target for levetiracetam's antiepileptic mechanism
    Matagne, Alain
    Margineanu, Doru-Georg
    Leclercq, Karine
    Dassesse, Donald
    Lambeng, Nathalie
    Klitgaard, Henrik
    EPILEPSIA, 2006, 47 : 226 - 226
  • [49] Measuring Synaptic Vesicle Endocytosis in Cultured Hippocampal Neurons
    Villarreal, Seth
    Lee, Sung Hoon
    Wu, Ling-Gang
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2017, (127):
  • [50] Monitoring synaptic loss in a rat model of stroke: a PET imaging study with [18F]SynVesT-2, radiotracer for the synaptic vesicle protein 2A (SV2A)
    Lyu, Xueying
    Toyonaga, Takuya
    Deng, Gang
    Huang, Yiyun
    Carson, Richard
    Zhou, Jiangbing
    Cai, Zhengxin
    JOURNAL OF NUCLEAR MEDICINE, 2020, 61
12345